Department of Orthopaedic Surgery and Physical Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
BMC Musculoskelet Disord. 2010 Oct 25;11:246. doi: 10.1186/1471-2474-11-246.
The efficacy of selective cox-2 inhibitors in postoperative pain reduction were usually compared with conventional non-selective conventional NSAIDs or other types of medicine. Previous studies also used selective cox-2 inhibitors as single postoperative dose, in continued mode, or in combination with other modalities. The purpose of this study was to compare analgesic efficacy of single preoperative administration of etoricoxib versus celecoxib for post-operative pain relief after arthroscopic anterior cruciate ligament reconstruction.
One hundred and two patients diagnosed as anterior cruciate ligament injury were randomized into 3 groups using opaque envelope. Both patients and surgeon were blinded to the allocation. All of the patients were operated by one orthopaedic surgeon under regional anesthesia. Each group was given either etoricoxib 120 mg., celecoxib 400 mg., or placebo 1 hour prior to operative incision. Post-operative pain intensity, time to first dose of analgesic requirement and numbers of analgesic used for pain control and adverse events were recorded periodically to 48 hours after surgery. We analyzed the data according to intention to treat principle.
Among 102 patients, 35 were in etoricoxib, 35 in celecoxib and 32 in placebo group. The mean age of the patients was 30 years and most of the injury came from sports injury. There were no significant differences in all demographic characteristics among groups. The etoricoxib group had significantly less pain intensity than the other two groups at recovery room and up to 8 hours period but no significance difference in all other evaluation point, while celecoxib showed no significantly difference from placebo at any time points. The time to first dose of analgesic medication, amount of analgesic used, patient's satisfaction with pain control and incidence of adverse events were also no significantly difference among three groups.
Etoricoxib is more effective than celecoxib and placebo for using as preemptive analgesia for acute postoperative pain control in patients underwent arthroscopic anterior cruciate ligament reconstruction.
NCT01017380.
选择性环氧化酶-2 抑制剂在减少术后疼痛方面的疗效通常与传统的非选择性非甾体抗炎药或其他类型的药物进行比较。先前的研究还使用选择性环氧化酶-2 抑制剂作为单一术后剂量，持续模式，或与其他方式联合使用。本研究旨在比较单次术前给予依托考昔与塞来昔布对关节镜下前交叉韧带重建术后疼痛缓解的疗效。
102 例诊断为前交叉韧带损伤的患者采用不透明信封法随机分为 3 组。患者和外科医生均对分组情况不知情。所有患者均由同一位骨科医生在区域麻醉下进行手术。每组患者分别给予依托考昔 120mg、塞来昔布 400mg 或安慰剂 1 小时后切开手术。术后定期记录疼痛强度、首次使用镇痛药的时间、用于控制疼痛的镇痛药用量以及不良反应的发生情况，直至术后 48 小时。我们根据意向治疗原则分析数据。
102 例患者中，依托考昔组 35 例，塞来昔布组 35 例，安慰剂组 32 例。患者平均年龄为 30 岁，多数损伤来自运动损伤。三组患者的所有人口统计学特征均无显著差异。依托考昔组在恢复室和 8 小时内的疼痛强度明显低于其他两组，但在所有其他评估点均无显著差异，而塞来昔布在任何时间点均与安慰剂无显著差异。首次使用镇痛药的时间、镇痛药用量、患者对疼痛控制的满意度和不良反应发生率在三组之间也无显著差异。
依托考昔作为超前镇痛药物用于关节镜下前交叉韧带重建术后急性疼痛控制，比塞来昔布和安慰剂更有效。
NCT01017380。
