Department of Advanced Biomedical Sciences, Pathology Section, Federico II University of Naples, Naples, Italy.
Department of Clinical Medicine and Surgery, Hematology Section, Federico II University of Naples, Naples, Italy.
Am J Clin Pathol. 2020 May 5;153(6):719-724. doi: 10.1093/ajcp/aqaa005.
Sjögren syndrome (SS) is considered as a major etiologic factor for primary salivary gland lymphoma (SGL). However, the percentage of SGL that is caused by SS (and thus the real impact of SS on SGL epidemiology) is unclear. We aimed to assess the prevalence of SS in patients with SGL through a systematic review and meta-analysis.
Electronic databases were searched for studies assessing the presence of SS in patients with SGL. Pooled prevalence of SS in SGL was calculated, with a subgroup analysis based on histotype (mucosa-associated lymphoid tissue [MALT] vs non-MALT).
Sixteen studies with 665 SGLs were included. Pooled prevalence of SS in SGL was 18.2%, with high heterogeneity among studies. In MALT SGL, the prevalence of SS was 29.5%, with moderate heterogeneity. In non-MALT SGL, the prevalence of SS was 0%, with null heterogeneity.
SS seems to be responsible for a significant but minor portion of SGLs. SS appears involved in MALT-type SGL but not in other histotypes.
干燥综合征（SS）被认为是原发性涎腺淋巴瘤（SGL）的主要病因。然而，由 SS 引起的 SGL 的比例（以及 SS 对 SGL 流行病学的实际影响）尚不清楚。我们旨在通过系统评价和荟萃分析评估 SGL 患者中 SS 的患病率。
电子数据库中检索评估 SGL 患者 SS 存在情况的研究。计算 SGL 中 SS 的总患病率，并根据组织学类型（黏膜相关淋巴组织[MALT]与非-MALT）进行亚组分析。
纳入了 16 项包含 665 例 SGL 的研究。SGL 中 SS 的总患病率为 18.2%，研究之间存在高度异质性。在 MALT SGL 中，SS 的患病率为 29.5%，异质性中度。在非-MALT SGL 中，SS 的患病率为 0%，异质性为零。
SS 似乎是 SGL 的一个重要但次要的原因。SS 似乎与 MALT 型 SGL 有关，但与其他组织学类型无关。
