Deparment of Women's Health, Faculty of Medicine and Health, Örebro University, 701 85, Örebro, Sweden.
Deparment of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, 701 85, Örebro, Sweden.
Cancer Causes Control. 2020 Apr;31(4):377-381. doi: 10.1007/s10552-020-01278-0. Epub 2020 Feb 19.
Örebro County introduced an updated screening program 2016 with primary HPV test for women over 30 years and prolonged screening, increasing the cut-off age from 56-60 to 64-70. The aim of this study was to investigate the prevalence of HPV genotypes and their correlation to histological changes in women, 10 years after exclusion from the screening program, due to an eventual implementation of a catch-up program including all women aged 60-70.
All women in Örebro County, born 1,946 (n = 1,968), were invited to a liquid-based cell sample with primary HPV screening. Samples were analyzed for hrHPV mRNA and positive samples were genotyped. hrHPV positive women were offered to do a conization.
Out of 809 participants, 31 (3.8%) were hrHPV positive, of these 22 did a conization. Histologically, 5/22 (23%) had LSIL and 5/22 (23%) had HSIL. Normal histology was found in 12/22 (55%). The most prevalent genotypes were HPV 16, 33, 52, 56, and 68. Of the women with HSIL, one case of cervical cancer was confirmed in a recone biopsy after 4 months.
The study showed considerable prevalence of hrHPV and histologically confirmed LSIL/HSIL. These data led to catch-up screening for women between 60 and 70 years when overlapping two screening strategies.
奥雷布洛县于 2016 年推出了一项更新的筛查计划，为 30 岁以上的女性提供主要的 HPV 检测，并延长了筛查时间，将截止年龄从 56-60 岁延长至 64-70 岁。本研究旨在调查 HPV 基因型的流行率及其与 10 年后因实施包括所有 60-70 岁女性的补种计划而被排除在筛查计划之外的女性的组织学变化之间的相关性。
奥雷布洛县所有 1946 年出生的女性（n=1968 人）都被邀请进行液基细胞样本的 HPV 初步筛查。对样本进行人乳头瘤病毒（hrHPV）mRNA 分析，对阳性样本进行基因分型。hrHPV 阳性女性被建议进行宫颈锥切术。
在 809 名参与者中，有 31 名（3.8%）为 hrHPV 阳性，其中 22 名进行了宫颈锥切术。组织学上，22 例中有 5 例（23%）为低度鳞状上皮内病变（LSIL），5 例（23%）为高度鳞状上皮内病变（HSIL）。在 22 例中，12 例（55%）为正常组织学。最常见的基因型是 HPV 16、33、52、56 和 68。在 HSIL 患者中，1 例宫颈癌在 4 个月后的再次宫颈活检中得到确诊。
该研究显示出相当高的人乳头瘤病毒感染率和组织学上证实的 LSIL/HSIL。这些数据导致了 60 至 70 岁女性的补种筛查，此时两种筛查策略重叠。
