School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
EMBO Rep. 2020 Apr 3;21(4):e50097. doi: 10.15252/embr.202050097. Epub 2020 Feb 20.
N -methyladenosine (m A) has emerged as a crucial molecular code to influence pluripotency and differentiation of diverse stem cells. A study in this issue now shows that, in intestinal stem cells, the m A reader protein YTHDF1 directs translational control of stemness in both m A- and Wnt-dependent manner [1].
N6-甲基腺苷（m6A）已成为影响多种干细胞多能性和分化的关键分子密码。本期一项研究表明，在肠干细胞中，m6A 阅读蛋白 YTHDF1 通过 m6A 和 Wnt 依赖的方式指导干性的翻译调控[1]。
