Department of Ultrasound, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, Guangdong, PR China.
Department of Internal Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang, PR China.
Biomark Med. 2020 Apr;14(5):381-389. doi: 10.2217/bmm-2019-0472. Epub 2020 Feb 20.
To explore whether elevated serum sortilin was associated with calcified carotid plaque and ischemic stroke. A total of 171 patients with cardiovascular risk factors were enrolled. Ultrasonography was performed to evaluate calcified plaques and noncalcified plaques. Serum sortilin concentration was measured by ELISA. Serum sortilin level was higher in patients with calcified carotid plaque and positively related to carotid plaque burden, but not with ischemic stroke during the follow-up. Multivariable logistic regression analysis revealed serum sortilin level was an independent determinant for calcified carotid plaque (p = 0.001). Receiving operating characteristic analysis showed an area under the curve of sortilin for carotid calcification was 0.759. Higher serum sortilin level was associated with carotid calcification and severe carotid plaque score.
探讨血清分选连接蛋白水平升高是否与颈动脉钙化斑块和缺血性卒中有关。共纳入 171 例心血管危险因素患者。应用超声评估颈动脉钙化斑块和非钙化斑块。采用 ELISA 法检测血清分选连接蛋白浓度。颈动脉钙化斑块患者的血清分选连接蛋白水平较高，与颈动脉斑块负荷呈正相关，但与随访期间的缺血性卒中无关。多变量 logistic 回归分析显示，血清分选连接蛋白水平是颈动脉钙化斑块的独立决定因素（p = 0.001）。受试者工作特征曲线分析显示，分选连接蛋白对颈动脉钙化的曲线下面积为 0.759。较高的血清分选连接蛋白水平与颈动脉钙化和严重颈动脉斑块评分相关。
