Department of Cosmetic Science and Technology, Seowon University, Cheongju, Republic of Korea.
College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.
J Asian Nat Prod Res. 2021 Jan;23(1):89-99. doi: 10.1080/10286020.2020.1724969. Epub 2020 Feb 20.
Human endothelial cells-derived polyphosphate (PolyP) is one of the pro-inflammatory mediators as suggested by the previous reports. Aloin is the major anthraquinone glycoside obtained from the species and exhibits anti-inflammatory and anti-oxidative activities. Aloin inhibits PolyP-mediated barrier disruption, the expressions of cell adhesion molecules, and adhesion/migration of leukocyte to HUVEC. PolyP-induced NF-κB activation and the productions of TNF-α and IL-6 were inhibited by aloin in HUVECs. These anti-inflammatory functions of aloin were confirmed in PolyP-injected mice. In conclusion, based on the anti-inflammatory effects of aloin in PolyP-mediated septic response, aloin has therapeutic potential for various systemic inflammatory diseases.
人内皮细胞衍生的多聚磷酸盐（PolyP）是先前报道的促炎介质之一。芦荟苷是从 物种中提取的主要蒽醌糖苷，具有抗炎和抗氧化活性。芦荟苷可抑制 PolyP 介导的屏障破坏、细胞黏附分子的表达以及白细胞与 HUVEC 的黏附和迁移。芦荟苷可抑制 PolyP 诱导的 NF-κB 激活以及 TNF-α 和 IL-6 的产生。在注射 PolyP 的小鼠中也证实了芦荟苷的这些抗炎作用。总之，基于芦荟苷在 PolyP 介导的败血症反应中的抗炎作用，芦荟苷具有治疗各种全身性炎症性疾病的潜力。
