Department of Otolaryngology, College of Medicine, 37950King Saud University, Riyadh, Saudi Arabia.
Department of Otorhinolaryngology, 37849King Fahad Medical City, Riyadh, Saudi Arabia.
Ear Nose Throat J. 2021 Sep;100(5_suppl):720S-727S. doi: 10.1177/0145561320904620. Epub 2020 Feb 20.
Chronic granulomatous invasive fungal sinusitis (CGIFS) is a peculiar disease of the paranasal sinuses due to its rarity, patient subset, and disease course. We describe 7 cases of histopathologically confirmed CGIFS with different treatment plans and varying outcomes. Of particular note was that one of these patients developed allergic fungal rhinosinusitis after complete resolution of his primary invasive disease, a finding that has never been reported in the literature. Another patient had an atypical fungal species () on fungal stain and culture, while one immunodeficient patient had a large intracerebral disease component and died after 2 months of treatment. We also present a review of the pertinent literature investigating this rare disease.
慢性肉芽肿性侵袭性真菌性鼻窦（CGIFS）是一种罕见的鼻窦疾病，由于其罕见性、患者亚组和疾病过程。我们描述了 7 例经组织病理学证实的 CGIFS 病例，这些病例有不同的治疗方案和不同的结果。值得注意的是，其中一名患者在原发性侵袭性疾病完全缓解后发生了变应性真菌性鼻鼻窦炎，这一发现从未在文献中报道过。另一名患者的真菌染色和培养显示有非典型真菌种属（），而一名免疫功能低下的患者有较大的颅内疾病成分，并在治疗 2 个月后死亡。我们还对该罕见疾病的相关文献进行了回顾。
