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神经科学已经为我们做了什么。

What neuroscience has already done for us.

作者信息

Sinclair Lindsey Isla

机构信息

Department of Population Health Sciences, University of Bristol, UK.

出版信息

BJPsych Bull. 2020 Jun;44(3):110-112. doi: 10.1192/bjb.2019.90.

DOI:10.1192/bjb.2019.90
PMID:32077401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8058836/
Abstract

Each of the components of the biopsychosocial model of mental illness is important for understanding mental illness. Biological and genetic abnormalities have been demonstrated in major mental illnesses. These are leading to changes in our understanding of these conditions, as well as our understanding of the link between life events and mental illness.

摘要

精神疾病生物心理社会模型的每个组成部分对于理解精神疾病都很重要。在主要精神疾病中已证实存在生物和基因异常。这些正导致我们对这些病症的理解发生变化,以及我们对生活事件与精神疾病之间联系的理解发生变化。

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Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.家族性 t(1;11)易位与白质结构完整性破坏和少突胶质细胞-髓鞘功能障碍有关。
Mol Psychiatry. 2019 Nov;24(11):1641-1654. doi: 10.1038/s41380-019-0505-2. Epub 2019 Sep 3.
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Improving access to genetic testing for adults with intellectual disability: A literature review and lessons from a quality improvement project in East London.提高智障成年人接受基因检测的机会:文献综述及东伦敦质量改进项目的经验教训。
Am J Med Genet B Neuropsychiatr Genet. 2019 Dec;180(8):566-575. doi: 10.1002/ajmg.b.32732. Epub 2019 May 11.
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Sensitive Periods for the Effect of Childhood Adversity on DNA Methylation: Results From a Prospective, Longitudinal Study.童年逆境对 DNA 甲基化影响的敏感期:一项前瞻性纵向研究的结果。
Biol Psychiatry. 2019 May 15;85(10):838-849. doi: 10.1016/j.biopsych.2018.12.023. Epub 2019 Jan 21.
4
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples.没有证据支持大样本中主要抑郁症的历史候选基因或候选基因-交互作用假说。
Am J Psychiatry. 2019 May 1;176(5):376-387. doi: 10.1176/appi.ajp.2018.18070881. Epub 2019 Mar 8.
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Child maltreatment, adaptive functioning, and polygenic risk: A structural equation mixture model.儿童虐待、适应功能和多基因风险:结构方程混合模型。
Dev Psychopathol. 2019 May;31(2):443-456. doi: 10.1017/S0954579419000014. Epub 2019 Mar 6.
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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.全基因组荟萃分析抑郁症鉴定出 102 个独立变异,并强调了前额叶脑区的重要性。
Nat Neurosci. 2019 Mar;22(3):343-352. doi: 10.1038/s41593-018-0326-7. Epub 2019 Feb 4.
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Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging.通过靶向 NFκB 信号通路逆转 16p13.11 号染色体微重复引起的增殖缺陷:患者源性神经前体细胞、大脑类器官和体内脑成像的综合研究。
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