多萜醇单磷酸酯对脂质膜通透性的影响。
Effect of dolichyl monophosphate on the permeability properties of lipid membranes.
作者信息
Alonso-Romanowski S, Feliz M R, Belocopitow E, Disalvo E A
机构信息
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Buenos Aires, Argentina.
出版信息
Biochim Biophys Acta. 1988 Dec 22;946(2):389-96. doi: 10.1016/0005-2736(88)90414-2.
The effect of dolichyl monophosphate on the permeability properties of dimyristoylphosphatidylcholine bilayers to alkaline cations, Ca2+ and glucose has been determined by stop-flow spectrophotometry. The results show that, in contrast to free dolichol effects, the monophosphate derivative increased the permeability following a decreasing order of the permeating particle size. Phase diagrams indicate that dolichyl monophosphate is fully incorporated into the phosphatidylcholine bilayer around 0.75% weight/weight ratio. For these ratios, the permeation of ions is higher in the gel than in the liquid crystalline state.
通过停流分光光度法测定了磷酸多萜醇对二肉豆蔻酰磷脂酰胆碱双层膜对碱性阳离子、Ca2+和葡萄糖的通透性的影响。结果表明，与游离多萜醇的作用相反，磷酸衍生物使通透性按照渗透颗粒大小的递减顺序增加。相图表明，磷酸多萜醇在约0.75%重量/重量比时完全融入磷脂酰胆碱双层膜。对于这些比例，凝胶态中离子的渗透率高于液晶态。
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