可见光介导的烯炔和二烯的硅氢化和氢膦酰化环化反应
Visible-Light Mediated Hydrosilylative and Hydrophosphorylative Cyclizations of Enynes and Dienes.
作者信息
Hou Hong, Xu Yue, Yang Haibo, Chen Xiaoyun, Yan Chaoguo, Shi Yaocheng, Zhu Shaoqun
机构信息
School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, China.
School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, China.
出版信息
Org Lett. 2020 Mar 6;22(5):1748-1753. doi: 10.1021/acs.orglett.0c00024. Epub 2020 Feb 20.
Described herein is a visible-light mediated intermolecular radical cyclization approach to access heterocycles. Heteroatom radicals, such as silicon and phosphorus atom radicals, were generated via direct hydrogen atom abstraction by the photoexcited catalyst species with hydro-silanes and phosphine oxides. The radical addition/cyclization/HAT (hydrogen atom transfer) reaction sequences of 1,6-enynes and 1,6-dienes were highly efficient delivering the desired heterocycles in good yields.
本文描述了一种用于构建杂环的可见光介导的分子间自由基环化方法。通过光激发的催化剂物种与硅烷和氧化膦直接夺取氢原子，生成杂原子自由基，如硅和磷原子自由基。1,6-烯炔和1,6-二烯的自由基加成/环化/氢原子转移（HAT）反应序列高效地以良好产率得到所需的杂环。
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