Hou Hong, Sun Yue, Pan Yingjie, Yu Huaguang, Han Ying, Shi Yaocheng, Yan Chaoguo, Zhu Shaoqun
School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225009, China.
Key Laboratory of Optoelectronic Chemical Materials and Devices, Ministry of Education, School of Chemical and Environmental Engineering, Jianghan University, Wuhan 430056, China.
J Org Chem. 2021 Jan 1;86(1):1273-1280. doi: 10.1021/acs.joc.0c02529. Epub 2020 Dec 7.
We herein described a selenylative cyclization reaction of enynes by the utilization of diselenides as radical sources. The visible-light irradiation of the reaction mixture enables the generation of the selenium atom radical to trigger the radical addition/cyclization/selenation sequences. Both terminal alkyne and internal alkyne derived 1,6-enynes were tested and suitable for the current synthetic protocol, delivering various kinds of selenium-containing cycles in good yields.
我们在此描述了一种利用二硒化物作为自由基源的烯炔的硒基环化反应。对反应混合物进行可见光照射能够产生硒原子自由基，从而引发自由基加成/环化/硒化序列。末端炔烃和内炔烃衍生的1,6-烯炔均经过测试，适用于当前的合成方案，能以良好的产率得到各种含硒环化物。
