Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.
Curr Stem Cell Res Ther. 2020;15(3):219-232. doi: 10.2174/1568026620666200220122536.
The liver is a vital organ for life and the only internal organ that is capable of natural regeneration. Although the liver has high regeneration capacity, excessive hepatocyte death can lead to liver failure. Various factors can lead to liver damage including drug abuse, some natural products, alcohol, hepatitis, and autoimmunity. Some models for studying liver injury are APAP-based model, Fas ligand (FasL), D-galactosamine/endotoxin (Gal/ET), Concanavalin A, and carbon tetrachloride-based models. The regeneration of the liver can be carried out using umbilical cord blood stem cells which have various advantages over other stem cell types used in liver transplantation. UCB-derived stem cells lack tumorigenicity, have karyotype stability and high immunomodulatory, low risk of graft versus host disease (GVHD), low risk of transmitting somatic mutations or viral infections, and low immunogenicity. They are readily available and their collection is safe and painless. This review focuses on recent development and modern trends in the use of umbilical cord stem cells for the regeneration of liver fibrosis.
肝脏是生命的重要器官，也是唯一能够自然再生的内部器官。尽管肝脏具有很强的再生能力，但过度的肝细胞死亡会导致肝功能衰竭。多种因素可导致肝损伤，包括药物滥用、某些天然产物、酒精、肝炎和自身免疫。研究肝损伤的一些模型有基于对乙酰氨基酚的模型、Fas 配体 (FasL)、半乳糖胺/内毒素 (Gal/ET)、刀豆蛋白 A 和四氯化碳模型。脐带血干细胞可用于肝脏再生，与其他用于肝移植的干细胞类型相比，脐带血干细胞具有多种优势。脐带血来源的干细胞无致瘤性，具有核型稳定性和高免疫调节作用、移植物抗宿主病 (GVHD) 风险低、体细胞突变或病毒感染风险低、免疫原性低。它们易于获得，采集安全无痛。本综述重点介绍了脐带干细胞在肝纤维化再生中的最新研究进展和现代趋势。
