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对比剂-free 高分辨率 3D 磁化传递成像，用于同时显示心肌瘢痕和心静脉。

Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization.

机构信息

School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, 3rd Floor Lambeth Wing, London, SE1 7EH, UK.

MR Research Collaborations, Siemens Healthcare Limited, Frimley, UK.

出版信息

MAGMA. 2020 Oct;33(5):627-640. doi: 10.1007/s10334-020-00833-9. Epub 2020 Feb 20.

DOI:10.1007/s10334-020-00833-9
PMID:32078075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7502043/
Abstract

OBJECTIVE

To develop a three-dimensional (3D) high-resolution free-breathing magnetization transfer ratio (MTR) sequence for contrast-free assessment of myocardial infarct and coronary vein anatomy.

MATERIALS AND METHODS

Two datasets with and without off-resonance magnetization transfer preparation were sequentially acquired to compute MTR. 2D image navigators enabled beat-to-beat translational and bin-to-bin non-rigid motion correction. Two different imaging sequences were explored. MTR scar localization was compared against 3D late gadolinium enhancement (LGE) in a porcine model of myocardial infarction. MTR variability across the left ventricle and vessel sharpness in the coronary veins were evaluated in healthy human subjects.

RESULTS

A decrease in MTR was observed in areas with LGE in all pigs (non-infarct: 25.1 ± 1.7% vs infarct: 16.8 ± 1.9%). The average infarct volume overlap on MTR and LGE was 62.5 ± 19.2%. In humans, mean MTR in myocardium was between 37 and 40%. Spatial variability was between 15 and 20% of the mean value. 3D whole heart MT-prepared datasets enabled coronary vein visualization with up to 8% improved vessel sharpness for non-rigid compared to translational motion correction.

DISCUSSION

MTR and LGE showed agreement in infarct detection and localization in a swine model. Free-breathing 3D MTR maps are feasible in humans but high spatial variability was observed. Further clinical studies are warranted.

摘要

目的

开发一种三维（3D）高分辨率自由呼吸磁化传递率（MTR）序列，用于无对比评估心肌梗死和冠状静脉解剖结构。

材料与方法

依次采集带有和不带有离频磁化传递准备的两个数据集以计算 MTR。2D 图像导航器实现了逐拍的平移和逐-bin 的非刚性运动校正。探索了两种不同的成像序列。在心肌梗死猪模型中，将 MTR 瘢痕定位与 3D 晚期钆增强（LGE）进行比较。在健康人体中，评估了左心室的 MTR 变异性和冠状静脉中的血管锐利度。

结果

所有猪的 LGE 区域均观察到 MTR 降低（非梗死区：25.1±1.7% vs 梗死区：16.8±1.9%）。MTR 和 LGE 的平均梗死体积重叠为 62.5±19.2%。在人体中，心肌的平均 MTR 在 37%至 40%之间。空间变异性在平均值的 15%至 20%之间。与平移运动校正相比，3D 全心脏 MT 准备数据集可实现冠状静脉可视化，非刚性校正可使血管锐利度提高 8%。

讨论

MTR 和 LGE 在猪模型中显示出在梗死检测和定位方面的一致性。自由呼吸 3D MTR 图谱在人体中是可行的，但观察到空间变异性较高。需要进一步的临床研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/a232fb4f2be4/10334_2020_833_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/c47adfb128f0/10334_2020_833_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/e813b0b43a06/10334_2020_833_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/5d9ac41a1095/10334_2020_833_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/45a0ceb4401c/10334_2020_833_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/db51ce0a4a4a/10334_2020_833_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/a232fb4f2be4/10334_2020_833_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/c47adfb128f0/10334_2020_833_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/ea49bd5bb022/10334_2020_833_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/2209a817c63c/10334_2020_833_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/e813b0b43a06/10334_2020_833_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/5d9ac41a1095/10334_2020_833_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/45a0ceb4401c/10334_2020_833_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/db51ce0a4a4a/10334_2020_833_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc59/7502043/a232fb4f2be4/10334_2020_833_Fig8_HTML.jpg

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