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Biophys J. 1988 Sep;54(3):393-6. doi: 10.1016/S0006-3495(88)82972-2.
2
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Comparison of a relatively toxic phospholipase A2 from Naja nigricollis snake venom with that of a relatively non-toxic phospholipase A2 from Hemachatus haemachatus snake venom--I. Enzymatic activity on free and membrane bound substrates.黑颈眼镜蛇蛇毒中一种相对有毒的磷脂酶A2与拟眼镜蛇蛇毒中一种相对无毒的磷脂酶A2的比较——I. 对游离和膜结合底物的酶活性
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[Effect of a "direct" hemolytic factor and phospholipse A2 from Middle-Asian cobra venom on erythrocytes].[中亚眼镜蛇毒中“直接”溶血因子和磷脂酶A2对红细胞的作用]
Biokhimiia. 1975 Jul-Aug;40(4):698-702.
6
Group II phospholipases A2 are indirectly cytolytic in the presence of exogenous phospholipid.在存在外源性磷脂的情况下，II 组磷脂酶 A2 具有间接细胞溶解作用。
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Biochemical and pharmacological screening of snake (Bothrops) venoms: characterization of components acting on blood coagulation and platelet aggregation.蛇（矛头蝮属）毒液的生化与药理学筛选：作用于血液凝固和血小板聚集的成分特性
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引用本文的文献

1
Methane-induced haemolysis of human erythrocytes.甲烷诱导的人红细胞溶血
Biochem J. 1995 Apr 15;307 ( Pt 2)(Pt 2):433-8. doi: 10.1042/bj3070433.
2
Direct visualization of phosphorylase-phosphorylase kinase complexes by scanning tunneling and atomic force microscopy.通过扫描隧道显微镜和原子力显微镜直接观察磷酸化酶-磷酸化酶激酶复合物
Biophys J. 1990 Dec;58(6):1437-48. doi: 10.1016/S0006-3495(90)82489-9.

本文引用的文献

1
Pressure and temperature effects on human red cell cation transport.压力和温度对人体红细胞阳离子转运的影响。
J Membr Biol. 1982;68(1):47-56. doi: 10.1007/BF01872253.
2
Ex vivo human platelet aggregation induced by decompression during reduced barometric pressure, hydrostatic, and hydrodynamic (Bernoulli) effect.在气压降低、流体静力学及流体动力学（伯努利）效应期间减压诱导的体外人血小板聚集。
Thromb Res. 1984 Mar 1;33(5):477-85. doi: 10.1016/0049-3848(84)90013-6.
3
Energy balance in red cell interactions.红细胞相互作用中的能量平衡。
Ann N Y Acad Sci. 1983;416:190-206. doi: 10.1111/j.1749-6632.1983.tb35189.x.
4
Energetics of membrane deformation and adhesion in cell and vesicle aggregation.细胞与囊泡聚集过程中膜变形和黏附的能量学
Ann N Y Acad Sci. 1983;416:13-33. doi: 10.1111/j.1749-6632.1983.tb35176.x.
5
Localization of red cell membrane constituents.红细胞膜成分的定位
Biochim Biophys Acta. 1973 Sep 10;300(2):159-82. doi: 10.1016/0304-4157(73)90003-8.
6
Selective release of integral proteins from human erythrocyte membranes by hydrostatic pressure.通过静水压力从人红细胞膜中选择性释放整合蛋白。
Biochim Biophys Acta. 1985 Dec 5;821(2):334-40. doi: 10.1016/0005-2736(85)90103-8.
7
Red blood cell deformation in shear flow. Effects of internal and external phase viscosity and of in vivo aging.剪切流中红细胞的变形。内、外相粘度及体内老化的影响。
Biophys J. 1985 May;47(5):695-704. doi: 10.1016/S0006-3495(85)83966-7.
8
Pressure effect on the rate of crystalline phase formation of L-alpha-dipalmitoylphosphatidylcholines in multilamellar dispersions.压力对多层分散体系中L-α-二棕榈酰磷脂酰胆碱晶相形成速率的影响
Biophys J. 1985 Feb;47(2 Pt 1):237-42. doi: 10.1016/s0006-3495(85)83896-0.
9
Structural changes in lipid bilayers and biological membranes caused hydrostatic pressure.静水压力导致脂质双层和生物膜的结构变化。
Biochemistry. 1986 Nov 18;25(23):7484-8. doi: 10.1021/bi00371a034.
10
Execution of "ARC" experiment on space shuttle "Discovery" STS 51-C: some results on aggregation of red blood cells under zero gravity.在“发现号”航天飞机STS 51-C上进行“ARC”实验：关于零重力下红细胞聚集的一些结果
Biorheology. 1986;23(4):331-47. doi: 10.3233/bir-1986-23403.

轻度压力可诱导红细胞对蛇毒磷脂酶A2溶血产生抗性。

Mild pressure induces resistance of erythrocytes to hemolysis by snake venom phospholipase A2.

作者信息

Halle D, Yedgar S

机构信息

Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel 91010.

出版信息

Biophys J. 1988 Sep;54(3):393-6. doi: 10.1016/S0006-3495(88)82972-2.

DOI:10.1016/S0006-3495(88)82972-2
PMID:3207832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1330338/
Abstract

It is generally assumed that mild pressure of a few atmospheres, such as that applied to blood cells during routine centrifugation, does not affect cell function. The results of the present study refute this notion. To explore the effect of mild pressure on cell function we examined its effect on the susceptibility of red blood cells (RBC) to hemolysis by snake venom phospholipase A2 (PLA2). Rat RBC were subjected to pressure of up to five atmospheres, returned to ambient pressure and interacted with PLA2 to induce hemolysis. The hemolysis was markedly decreased with increasing the pressure applied before induction of hemolysis. Application of such a pressure induces the shedding of a chemical factor, as yet uncharacterized, which facilitates the action of PLA2 on RBC.

摘要

一般认为，几个大气压的轻微压力，如在常规离心过程中施加于血细胞的压力，不会影响细胞功能。本研究结果反驳了这一观点。为了探究轻微压力对细胞功能的影响，我们检测了其对红细胞（RBC）对蛇毒磷脂酶A2（PLA2）溶血敏感性的影响。将大鼠红细胞置于高达五个大气压的压力下，恢复到常压后与PLA2相互作用以诱导溶血。随着溶血诱导前施加压力的增加，溶血明显减少。施加这样的压力会诱导一种尚未明确特征的化学因子的释放，该因子促进PLA2对红细胞的作用。