靶向心力衰竭中的与年龄相关的通路。
Targeting Age-Related Pathways in Heart Failure.
机构信息
From the Corrigan Minehan Heart Center, Massachusetts General Hospital, Harvard Medical School, Boston (H.L., M.H.H., J.R., L.E.T., J.D.R., A.R.).
Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston (J.R.).
出版信息
Circ Res. 2020 Feb 14;126(4):533-551. doi: 10.1161/CIRCRESAHA.119.315889. Epub 2020 Feb 13.
Abstract
During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming increasingly urgent as the elderly population continues to grow. Our understanding of cardiac aging, and aging in general, is limited. However, recent studies of age-related decline and its prevention through interventions like exercise have revealed novel pathological and cardioprotective pathways. In this review, we summarize recent findings concerning the molecular mechanisms of age-related heart failure and highlight exercise as a valuable experimental platform for the discovery of much-needed novel therapeutic targets in this chronic disease.
摘要
随着老年人口的不断增长，对抗与年龄相关的心脏衰退的干预措施的需求变得越来越迫切。在心脏衰老和一般衰老方面，我们的了解有限。然而，最近关于衰老相关衰退及其通过运动等干预措施的预防的研究揭示了新的病理和心脏保护途径。在这篇综述中，我们总结了与年龄相关性心力衰竭的分子机制有关的最近发现，并强调运动是发现这种慢性疾病急需的新治疗靶点的宝贵实验平台。
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