Buck Institute for Research on Aging, Novato, CA, USA.
Nature. 2019 Jul;571(7764):183-192. doi: 10.1038/s41586-019-1365-2. Epub 2019 Jul 10.
For several decades, understanding ageing and the processes that limit lifespan have challenged biologists. Thirty years ago, the biology of ageing gained unprecedented scientific credibility through the identification of gene variants that extend the lifespan of multicellular model organisms. Here we summarize the milestones that mark this scientific triumph, discuss different ageing pathways and processes, and suggest that ageing research is entering a new era that has unique medical, commercial and societal implications. We argue that this era marks an inflection point, not only in ageing research but also for all biological research that affects the human healthspan.
几十年来，理解衰老过程和限制寿命的因素一直是生物学家面临的挑战。三十年前，通过鉴定延长多细胞模式生物寿命的基因变异，衰老生物学获得了前所未有的科学可信度。在这里，我们总结了标志这一科学胜利的里程碑，讨论了不同的衰老途径和过程，并提出衰老研究正在进入一个具有独特医学、商业和社会意义的新时代。我们认为，这一时代不仅标志着衰老研究的转折点，而且标志着所有影响人类健康寿命的生物学研究的转折点。
