Kodama Asako, Kobayashi Fumitaka, Yang Hao Yung, Fukagawa Kazumi, Yazu Hiroyuki, Fujishima Hiroshi
Department of Ophthalmology, Eiju General Hospital, Tokyo 110-8645, Japan.
Smile Eye Clinic, Kanagawa 227-0062, Japan.
Diagnostics (Basel). 2020 Feb 17;10(2):109. doi: 10.3390/diagnostics10020109.
Diagnosis of conjunctivitis can be sometimes difficult, especially in cases of severe conjunctivitis and those involving both eyes. In this study, we performed commercial tests for adenovirus (Capilia Adeno Eye) and total tear IgE (Allerwatch) in a single visit in patients with bilateral conjunctivitis to examine if, and by how much, the combination of these two tests would improve the diagnostic accuracy of conjunctivitis.
The study included sixty patients with relatively severe conjunctivitis in both eyes within a week of consulting our clinic and who had no previous treatment. Capilia Adeno Eye and Allerwatch tests were performed.
A significantly higher number of cases (55/60) were diagnosed when both tests were evaluated than with either test (Capilia Adeno Eye (12/60; < 0.001) or Allerwatch (44/60; < 0.005)) alone. The positivity rate of Allerwatch was significantly higher than that of Capilia Adeno Eye ( < 0.001). The diagnosis rate of atopic keratoconjunctivitis was 100% in patients with allergic conjunctivitis, but there was no significant difference in positivity compared with other types of allergic conjunctivitis.
Testing patients with both Capilia Adeno Eye and Allerwatch improves the diagnostic accuracy for conjunctivitis and can diagnose more than 90% of cases. Detection of adenovirus antigen and IgE in tears, using these simple and rapid methods, will be useful for early diagnosis and prevention of adenoviral conjunctivitis.
结膜炎的诊断有时会很困难，尤其是在严重结膜炎和双眼受累的情况下。在本研究中，我们对双侧结膜炎患者进行了一次就诊时的腺病毒（Capilia Adeno Eye）和总泪液IgE（Allerwatch）商业检测，以检查这两种检测方法的组合是否以及在多大程度上能提高结膜炎的诊断准确性。
该研究纳入了60例在就诊我们诊所一周内双眼患有相对严重结膜炎且未接受过先前治疗的患者。进行了Capilia Adeno Eye和Allerwatch检测。
与单独使用任何一种检测方法（Capilia Adeno Eye（12/60；<0.001）或Allerwatch（44/60；<0.005））相比，同时评估两种检测时诊断出的病例数显著更多（55/60）。Allerwatch的阳性率显著高于Capilia Adeno Eye（<0.001）。变应性角结膜炎患者的诊断率为100%，但与其他类型的变应性结膜炎相比，阳性率无显著差异。
对患者同时进行Capilia Adeno Eye和Allerwatch检测可提高结膜炎的诊断准确性，能诊断超过90%的病例。使用这些简单快速的方法检测泪液中的腺病毒抗原和IgE，将有助于腺病毒性结膜炎的早期诊断和预防。
