Department of Research and Development, Sunchang Research Center for Fermentation Microbes, Sunchang 56048, Korea.
Department of Research and Development, Daily Manufacturing, Incorporated, Rockwell, North Carolina 28138, United States.
J Agric Food Chem. 2020 Nov 18;68(46):13168-13178. doi: 10.1021/acs.jafc.9b07962. Epub 2020 Apr 2.
We determined that consuming chungkookjang fermented by (BS) or (BA) alleviated hyperglycemia in partially pancreatectomized (Px) rats, an Asian type 2 diabetic (T2D) animal model. Px rats had deteriorated glucose metabolism with decreased glucose-stimulated insulin secretion and insulin sensitivity. Insulin secretion capacity was improved in the ascending order of the Px-control, positive control (3 mg of metformin/kg of body weight), BS (4.5% BS diet), BA (4.5% BA diet), and normal-control (sham-operated rats). BA and BS increased β-cell mass and decreased malondialdehyde contents and tumor necrosis factor α expression in the islets. BA increased hepatic peroxisome proliferator-activated receptor (PPAR)-α and PPAR-β similar to the positive control. , , and () increased and decreased in the BA and BS compared to the Px-control. BA prevented the decrease in the villi area and the number of goblet cells in intestinal tissues. In conclusion, BA improved glucose regulation by potentiating insulin secretion and reducing insulin resistance while maintaining gut mucin contents by improving gut microbiota in lean T2D rats.
我们确定，（BS）或（BA）发酵的chungkookjang 可缓解部分胰腺切除（Px）大鼠的高血糖，这是一种亚洲 2 型糖尿病（T2D）动物模型。Px 大鼠的葡萄糖代谢恶化，葡萄糖刺激的胰岛素分泌和胰岛素敏感性降低。胰岛素分泌能力按 Px-对照、阳性对照（3 毫克二甲双胍/千克体重）、BS（4.5%BS 饮食）、BA（4.5%BA 饮食）和正常对照（假手术大鼠）的顺序升高。BA 和 BS 增加了胰岛中的β细胞质量，并降低了丙二醛含量和肿瘤坏死因子α的表达。BA 增加了肝过氧化物酶体增殖物激活受体（PPAR）-α 和 PPAR-β，与阳性对照相似。与 Px-对照相比，BA 和 BS 中的和增加，而减少。BA 可防止肠组织绒毛面积和杯状细胞数量减少。总之，BA 通过增强胰岛素分泌和降低胰岛素抵抗来改善葡萄糖调节，同时通过改善肠道微生物群来维持肠道粘蛋白含量，从而预防瘦 T2D 大鼠的肠道粘蛋白含量降低。
