Department of Laboratory Medicine, Huadong Hospital affiliated to Fudan University, Shanghai 200040, PR China.
Shanghai Key Laboratory of Clinical Geriatric Medicine affiliated to Shanghai 200040, PR China.
Future Microbiol. 2020 Feb;15:163-175. doi: 10.2217/fmb-2019-0283. Epub 2020 Feb 21.
To identify intestinal microbiota compositions in elderly functional constipation (FC) patients. Fecal samples from 61 FC patients and 48 healthy age-matched volunteers were analyzed through 16S rRNA gene sequencing. The intestinal microbiota compositions of FC patients were significantly different from healthy controls. Additionally, the species diversity of healthy controls was greater than that of FC patients. Indeed, the abundance of and was significantly decreased, whereas that of , , , and was remarkably increased in FC patients. Elderly FC patients appear to have a unique intestinal microbiota profile. Our findings should provide insight regarding the pathogenic mechanism of FC and evidence for exploring new therapeutic strategies in elderly FC patients.
鉴定老年功能性便秘（FC）患者的肠道微生物组成。方法：通过 16S rRNA 基因测序分析 61 例 FC 患者和 48 例健康年龄匹配志愿者的粪便样本。结果：FC 患者的肠道微生物组成与健康对照组有显著差异。此外，健康对照组的物种多样性大于 FC 患者。事实上，在 FC 患者中， 和 的丰度显著降低，而 、 、 、 和 的丰度显著增加。结论：老年 FC 患者似乎具有独特的肠道微生物特征。我们的研究结果为 FC 的发病机制提供了新的见解，并为探索老年 FC 患者的新治疗策略提供了依据。
