Wang Yajun, Zhang Xueni, Qing Mengli, Dang Wen, Bai Xuemei, Wang Yingjie, Zhou Di, Zhu Lingjuan, Qing Degang, Zhang Juan, Chen Gang, Li Ning
School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xinjiang Institute of Chinese Materia Medica and Ethnical Materia, Xinjiang Key Laboratory of Chinese Materia Medica and Ethnic Materia Medica, Urumqi 830002, China.
Acta Pharm Sin B. 2025 Jul;15(7):3372-3403. doi: 10.1016/j.apsb.2025.05.011. Epub 2025 May 22.
Intestinal aging is central to systemic aging, characterized by a progressive decline in intestinal structure and function. The core mechanisms involve dysregulation of epithelial cell renewal and gut microbiota dysbiosis. In addition to previous results in model organisms like , recent studies have shown that in mammalian models, aging causes increased intestinal permeability and intestinal-derived systemic inflammation, thereby affecting longevity. Therefore, anti-intestinal aging can be an important strategy for reducing frailty and promoting longevity. There are three key gaps remaining in the study of intestinal aging: (1) overemphasis on aging-related diseases rather than the primary aging mechanisms; (2) lack of specific drugs or treatments to prevent or treat intestinal aging; (3) limited aging-specific dysbiosis research. In this review, the basic structures and renewal mechanisms of intestinal epithelium, and mechanisms and potential therapies for intestinal aging are discussed to advance understanding of the causes, consequences, and treatments of age-related intestinal dysfunction.
肠道衰老对于全身衰老至关重要，其特征为肠道结构和功能逐渐衰退。核心机制包括上皮细胞更新失调和肠道微生物群失调。除了之前在诸如 等模式生物中取得的研究成果外，最近的研究表明，在哺乳动物模型中，衰老会导致肠道通透性增加和肠道源性全身炎症，从而影响寿命。因此，抗肠道衰老可能是减轻虚弱和促进长寿的重要策略。肠道衰老研究仍存在三个关键空白：（1）过度关注与衰老相关的疾病而非主要衰老机制；（2）缺乏预防或治疗肠道衰老的特定药物或疗法；（3）针对衰老特异性失调的研究有限。在本综述中，我们将讨论肠道上皮的基本结构和更新机制，以及肠道衰老的机制和潜在疗法，以增进对与年龄相关的肠道功能障碍的病因、后果及治疗方法的理解。
