School of Nursing and Midwifery, University of Southern Queensland, Toowoomba, Australia.
Division of Research and Innovation, University of Southern Queensland, Toowoomba, Australia.
Syst Rev. 2020 Feb 20;9(1):37. doi: 10.1186/s13643-020-01293-x.
Surgical site infections (SSIs) are among the most common healthcare-associated infections. Under-nutrition is an important risk factor for SSIs and can lead to delayed wound healing and longer hospital stays. Oral nutritional supplements are prescribed to reduce the risk of infection and improve health status, but data from randomised controlled trials (RCTs) have shown mixed results. Thus, the objective of our planned systematic review is to evaluate oral nutritional supplements on preventing SSIs in adult surgical patients METHODS: RCTs conducted in adult surgical patients who receive oral nutritional support will be included. The primary outcome will be the incidence of SSIs (within 30 days of surgery or within 90 days for joint replacement surgery). Secondary outcomes will be changes in nutritional status, mortality, health-related quality of life and costs. Literature searches will be conducted in several electronic databases (from inception onwards): MEDLINE, Embase, CINAHL and The Cochrane Central Register of Controlled Trials (CENTRAL). Grey literature will be identified through searching clinical trial registers and dissertation databases. Two reviewers will independently screen all citations, full-text articles and abstract data. The study methodological quality (or bias) will be appraised using the Cochrane risk of bias tool. If feasible, we will conduct random effects meta-analysis where appropriate.
This systematic review will evaluate the evidence for pre- and post-surgical intervention with oral nutritional supplements in adults. Findings from this planned review may inform subsequent nutritional interventions for hospitalised patients who undergo surgery.
PROSPERO CRD42020140954.
手术部位感染（SSI）是最常见的医院获得性感染之一。营养不良是 SSI 的一个重要危险因素，可导致伤口愈合延迟和住院时间延长。口服营养补充剂可用于降低感染风险并改善健康状况，但随机对照试验（RCT）的数据显示结果喜忧参半。因此，我们计划进行系统评价的目的是评估口服营养补充剂对预防成年手术患者 SSI 的作用。
将纳入接受口服营养支持的成年手术患者的 RCT。主要结局为 SSI 发生率（术后 30 天内或关节置换术后 90 天内）。次要结局为营养状况、死亡率、健康相关生活质量和成本的变化。将从各个电子数据库（从建立开始）进行文献检索：MEDLINE、Embase、CINAHL 和 The Cochrane Central Register of Controlled Trials（CENTRAL）。将通过搜索临床试验登记处和论文数据库来确定灰色文献。两名审查员将独立筛选所有引用、全文文章和摘要数据。使用 Cochrane 偏倚风险工具评估研究方法学质量（或偏倚）。如果可行，我们将在适当的情况下进行随机效应荟萃分析。
本系统评价将评估口服营养补充剂在成年患者术前和术后干预的证据。该计划审查的结果可能为接受手术的住院患者的后续营养干预提供信息。
PROSPERO CRD42020140954。
