阿托品处理的家兔中迷走神经刺激和嘌呤化合物引发的胃运动反应
Gastric motor responses elicited by vagal stimulation and purine compounds in the atropine-treated rabbit.
作者信息
Beck K, Calamai F, Staderini G, Susini T
机构信息
Department of Physiology, University of Florence, Italy.
出版信息
Br J Pharmacol. 1988 Aug;94(4):1157-66. doi: 10.1111/j.1476-5381.1988.tb11634.x.
Abstract
- The effects of vagal inhibitory stimulation and of purine compounds were studied in the rabbit stomach. 2. Gastric motility was assessed by the balloon method. Vagal nerves were electrically stimulated at the neck. Purine compounds were injected intra-arterially. 3. In the atropine-treated rabbit, vagal stimulation caused relaxant motor responses followed by a rebound contraction. 4. Among the purine compounds, only ADP and ATP caused relaxant motor responses similar to the effects of vagal inhibitory stimulation. However, the relaxation produced by ATP was more powerful than that due to ADP, especially at lower infusion rates. 5. Vagal inhibitory responses were recorded during and after infusion of ATP. When relaxation by ATP was fully developed, vagal inhibitory stimulation was ineffective. At the highest infusion rates of ATP, a depression of the vagal inhibitory motility was also observed after cessation of the infusion. 6. Relaxant responses to ATP and vagal inhibitory stimulation were not influenced by theophylline, scarcely affected by alpha,beta-methylene ATP, but were reduced or blocked by reactive blue 2. 7. The results are consistent with ATP being an inhibitory neurotransmitter in the stomach of the rabbit.
摘要
- 研究了迷走神经抑制性刺激和嘌呤化合物对兔胃的影响。2. 通过气囊法评估胃动力。在颈部对迷走神经进行电刺激。嘌呤化合物经动脉注射。3. 在阿托品处理的兔中，迷走神经刺激引起松弛性运动反应，随后出现反弹性收缩。4. 在嘌呤化合物中，只有二磷酸腺苷（ADP）和三磷酸腺苷（ATP）引起类似于迷走神经抑制性刺激作用的松弛性运动反应。然而，ATP产生的松弛作用比ADP更强，尤其是在较低输注速率时。5. 在输注ATP期间和之后记录到迷走神经抑制反应。当ATP引起的松弛充分发展时，迷走神经抑制性刺激无效。在ATP的最高输注速率下，输注停止后也观察到迷走神经抑制性动力的抑制。6. 对ATP和迷走神经抑制性刺激的松弛反应不受茶碱影响，几乎不受α,β-亚甲基ATP影响，但被活性蓝2减弱或阻断。7. 结果表明ATP是兔胃中的一种抑制性神经递质。
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