Departments of Pediatrics.
Medicine and Pediatrics, Division of Adult and Pediatric Endocrinology.
J Pediatr Hematol Oncol. 2020 Jul;42(5):e352-e354. doi: 10.1097/MPH.0000000000001755.
The incidence of pediatric venous thromboembolism (VTE) has been increasing in the past few decades and can be associated with significant mortality and morbidity. There are known risk factors associated with VTE, including estrogen therapy. However, the relationship between testosterone and VTE remains unclear. Here, we present a 17-year-old female-to-male transgender patient without a history of inherited thrombophilia, who developed pulmonary embolism while receiving testosterone injections for gender dysphoria. Despite the limited data on testosterone and the risk of VTE, health care providers should counsel patients and family about the possible increased risk of VTE when starting testosterone.
在过去几十年中，儿科静脉血栓栓塞症（VTE）的发病率一直在上升，并且可能与显著的死亡率和发病率相关。存在与 VTE 相关的已知风险因素，包括雌激素治疗。然而，睾丸激素与 VTE 之间的关系尚不清楚。在这里，我们介绍了一位 17 岁的女性到男性跨性别者，她在接受性别焦虑症的睾丸激素注射治疗时发生了肺栓塞，且没有遗传性血栓形成倾向的病史。尽管关于睾丸激素和 VTE 风险的数据有限，但医务人员在开始使用睾丸激素时，应告知患者和家属 VTE 风险增加的可能性。
