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一种用于 7T 猪心脏并行磁共振成像的新型单表面非对称 8Tx/16Rx 线圈阵列。

A Novel Mono-surface Antisymmetric 8Tx/16Rx Coil Array for Parallel Transmit Cardiac MRI in Pigs at 7T.

机构信息

Chair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Wuerzburg, D-97078, Wuerzburg, Germany.

出版信息

Sci Rep. 2020 Feb 20;10(1):3117. doi: 10.1038/s41598-020-59949-6.

DOI:10.1038/s41598-020-59949-6
PMID:32080274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7033245/
Abstract

A novel mono-surface antisymmetric 16-element transmit/receive (Tx/Rx) coil array was designed, simulated, constructed, and tested for cardiac magnetic resonance imaging (cMRI) in pigs at 7 T. The cardiac array comprised of a mono-surface 16-loops with two central elements arranged anti-symmetrically and flanked by seven elements on either side. The array was configured for parallel transmit (pTx) mode to have an eight channel transmit and 16-channel receive (8Tx/16Rx) coil array. Electromagnetic (EM) simulations, bench-top measurements, phantom, and MRI experiments with two pig cadavers (68 and 46 kg) were performed. Finally, the coil was used in pilot in-vivo measurements with a 60 kg pig. Flip angle (FA), geometry factor (g-factor), signal-to-noise ratio (SNR) maps, and high-resolution cardiac images were acquired with an in-plane resolution of 0.6 mm × 0.6 mm (in-vivo) and 0.3 mm × 0.3 mm (ex-vivo). The mean g-factor over the heart was 1.26 (R = 6). Static phase [Formula: see text] shimming in a pig body phantom with the optimal phase vectors makes possible to improve the [Formula: see text] homogeneity by factor > 2 and transmit efficiency by factor > 3 compared to zero phases (before RF shimming). Parallel imaging performed in the in-vivo measurements demonstrated well preserved diagnostic quality of the resulting images at acceleration factors up to R = 6. The described hardware design can be adapted for arrays optimized for animals and humans with a larger number of elements (32-64) while maintaining good decoupling for various MRI applications at UHF (e.g., cardiac, head, and spine).

摘要

设计、模拟、构建了一种新型单表面反对称 16 元发射/接收 (Tx/Rx) 线圈阵列,用于在 7T 下对猪的心脏磁共振成像 (cMRI) 进行研究。该心脏阵列由一个单表面 16 个线圈组成,两个中心线圈呈反对称排列,两侧各有 7 个线圈。该阵列被配置为并行发射 (pTx) 模式,具有 8 个发射通道和 16 个接收通道 (8Tx/16Rx) 线圈阵列。进行了电磁 (EM) 模拟、台式测量、体模和具有两个猪尸体 (68 和 46kg) 的 MRI 实验。最后,该线圈在一个 60kg 的猪身上进行了初步的体内测量。使用平面分辨率为 0.6mm×0.6mm(体内)和 0.3mm×0.3mm(离体)的翻转角 (FA)、几何因子 (g-因子)、信噪比 (SNR) 图和高分辨率心脏图像。心脏的平均 g-因子为 1.26 (R=6)。在猪体模中使用最佳相位矢量进行静态相位 [Formula: see text] 调谐可以使 [Formula: see text] 均匀性提高 2 倍以上,与零相位(在 RF 调谐之前)相比,传输效率提高 3 倍以上。在体内测量中进行的并行成像显示,在加速因子高达 R=6 时,所得图像具有良好的诊断质量。所描述的硬件设计可以适应针对动物和人类优化的具有更多元件 (32-64) 的阵列,同时在 UHF 下保持各种 MRI 应用的良好解耦(例如心脏、头部和脊柱)。

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本文引用的文献

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J Magn Reson. 2019 Aug;305:195-208. doi: 10.1016/j.jmr.2019.07.004. Epub 2019 Jul 5.
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A 7T spine array based on electric dipole transmitters.一种基于电偶极子发射器的7T脊柱阵列。
Magn Reson Med. 2015 Oct;74(4):1189-97. doi: 10.1002/mrm.25817. Epub 2015 Jul 20.
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16-channel bow tie antenna transceiver array for cardiac MR at 7.0 tesla.用于7.0特斯拉心脏磁共振成像的16通道领结式天线收发阵列
在 7T 下的心肌梗死大动物模型中心功能:基于深度学习的自动分割提高了可重复性。
Sci Rep. 2024 May 14;14(1):11009. doi: 10.1038/s41598-024-61417-4.
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High-resolution imaging of the excised porcine heart at a whole-body 7 T MRI system using an 8Tx/16Rx pTx coil.在全身 7T MRI 系统上使用 8Tx/16Rx pTx 线圈对切除的猪心进行高分辨率成像。
MAGMA. 2023 Apr;36(2):279-293. doi: 10.1007/s10334-023-01077-z. Epub 2023 Apr 7.
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