Niendorf Thoralf, Paul Katharina, Oezerdem Celal, Graessl Andreas, Klix Sabrina, Huelnhagen Till, Hezel Fabian, Rieger Jan, Waiczies Helmar, Frahm Jens, Nagel Armin M, Oberacker Eva, Winter Lukas
Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany.
NMR Biomed. 2016 Sep;29(9):1173-97. doi: 10.1002/nbm.3268. Epub 2015 Feb 23.
The objective of this study was to document and review advances and groundbreaking progress in cardiac and body MR at ultrahigh fields (UHF, B0 ≥ 7.0 T) with the goal to attract talent, clinical adopters, collaborations and resources to the biomedical and diagnostic imaging communities. This review surveys traits, advantages and challenges of cardiac and body MR at 7.0 T. The considerations run the gamut from technical advances to clinical opportunities. Key concepts, emerging technologies, practical considerations, frontier applications and future directions of UHF body and cardiac MR are provided. Examples of UHF cardiac and body imaging strategies are demonstrated. Their added value over the kindred counterparts at lower fields is explored along with an outline of research promises. The achievements of cardiac and body UHF-MR are powerful motivators and enablers, since extra speed, signal and imaging capabilities may be invested to overcome the fundamental constraints that continue to hamper traditional cardiac and body MR applications. If practical obstacles, concomitant physics effects and technical impediments can be overcome in equal measure, sophisticated cardiac and body UHF-MR will help to open the door to new MRI and MRS approaches for basic research and clinical science, with the lessons learned at 7.0 T being transferred into broad clinical use including diagnostics and therapy guiding at lower fields. Copyright © 2015 John Wiley & Sons, Ltd.
本研究的目的是记录和回顾超高场（UHF，B0≥7.0 T）心脏和体部磁共振成像的进展和突破性成果，旨在吸引人才、临床应用者、合作项目及资源进入生物医学和诊断成像领域。本综述探讨了7.0 T心脏和体部磁共振成像的特点、优势及挑战。考虑因素涵盖了从技术进展到临床应用机会等各个方面。文中提供了超高场体部和心脏磁共振成像的关键概念、新兴技术、实际考量、前沿应用及未来发展方向。展示了超高场心脏和体部成像策略的实例。探讨了其相较于低场同类成像的附加价值，并概述了研究前景。心脏和体部超高场磁共振成像的成果是强大的推动因素和助力手段，因为可以利用额外的速度、信号及成像能力来克服那些持续阻碍传统心脏和体部磁共振应用的基本限制。如果能在同等程度上克服实际障碍、伴随的物理效应及技术阻碍，先进的心脏和体部超高场磁共振成像将有助于为基础研究和临床科学开启新的磁共振成像和磁共振波谱方法之门，7.0 T磁共振成像所积累的经验也将推广至包括低场诊断和治疗指导在内的广泛临床应用中。版权所有© 2015约翰威立父子出版公司。
