Tarttelin M F, Gorski R A
Department of Physiology and Anatomy, Massey University, Palmerston North, New Zealand.
Brain Res. 1988 Jul 26;456(2):271-4. doi: 10.1016/0006-8993(88)90227-2.
The volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) of the male rat brain is larger than that of the female. In the female rat, treatment with diethylstilbestrol (DES), either perinatally (from day 16 of gestation to postnatal day 10), or postnatally (birth to day 10) was equally effective in increasing the volume of SDN-POA compared to controls. Prenatal treatment (day 16 of gestation to birth) with DES also increased the volume of the SDN-POA but this increase was significantly smaller than that achieved with the other treatments. These results confirm the effectiveness of DES in increasing the volume of the SDN-POA in the female rat brain, and prove that the differentiating SDN-POA is very receptive to hormone influences in the early postnatal period.
雄性大鼠脑视前区性二态核（SDN-POA）的体积大于雌性。在雌性大鼠中，围产期（从妊娠第16天至出生后第10天）或出生后（出生至第10天）用己烯雌酚（DES）治疗，与对照组相比，在增加SDN-POA体积方面同样有效。产前（妊娠第16天至出生）用DES治疗也增加了SDN-POA的体积，但这种增加明显小于其他治疗方法所达到的增加量。这些结果证实了DES在增加雌性大鼠脑SDN-POA体积方面的有效性，并证明正在分化的SDN-POA在出生后早期对激素影响非常敏感。
