Sattelle D B, Sepúlveda M I, Shinozaki H, Ishida M
Department of Zoology, University of Cambridge, United Kongdom.
Arch Insect Biochem Physiol. 1994;25(2):87-94. doi: 10.1002/arch.940250202.
Acromelic acid, a naturally occurring kainoid, isolated from the mushroom Clitocybe acromelalga, is a weak displacer of [3H]L-glutamate binding to cockroach (Periplaneta americana) nerve cord membranes. Acromelic acid (1 mM) displaces approximately 60% of specifically bound [3H]L-glutamate. When applied by bath perfusion to the cell body membrane of the cockroach fast coxal depressor motor neurone, acromelic acid generated slow, prolonged, dose-dependent depolarizations at concentrations of 0.3 microM and above. Thus acromelic acid is among the most potent of the excitatory amino acids tested to date on insect neurones.
肢端酸是一种天然存在的红藻氨酸类似物，从蘑菇顶孢小奥德蘑中分离得到，它是[³H]L-谷氨酸与蟑螂（美洲大蠊）神经索膜结合的弱置换剂。肢端酸（1 mM）可置换约60%特异性结合的[³H]L-谷氨酸。当通过浴槽灌流施加到蟑螂快速髋屈肌抑制运动神经元的细胞体膜上时，肢端酸在浓度为0.3 microM及以上时会产生缓慢、持久、剂量依赖性的去极化。因此，肢端酸是迄今为止在昆虫神经元上测试的最有效的兴奋性氨基酸之一。
