Najam N
Department of Applied Psychology, University of Punjab, Lahore, Pakistan.
Brain Res Bull. 1988 Oct;21(4):571-4. doi: 10.1016/0361-9230(88)90194-3.
The effect of chronic dopamine receptor blockage on ventro-medial hypothalamic lesion induced hyperphagia and obesity was studied. Rats with electrolytic ventromedial hypothalamic (VMH) lesions were treated chronically with either haloperidol (DA antagonist) or vehicle solution. Food intake of rats with VMH lesions fell well below baseline levels. Additionally, these animals started losing body weight within 24 hours of the initiation of treatment and continued to lose weight throughout the treatment period. When the treatment was discontinued these animals resumed overeating and regained body weights. The food intakes and body weights of unlesioned rats treated with either haloperidol or vehicle, and VMH lesioned rats treated with vehicle, were not affected by these treatments.
研究了慢性多巴胺受体阻断对腹内侧下丘脑损伤诱导的食欲亢进和肥胖的影响。用电解损伤腹内侧下丘脑（VMH）的大鼠长期接受氟哌啶醇（多巴胺拮抗剂）或赋形剂溶液治疗。VMH损伤大鼠的食物摄入量远低于基线水平。此外，这些动物在治疗开始后的24小时内开始体重减轻，并在整个治疗期间持续减重。当停止治疗时，这些动物恢复暴饮暴食并重新获得体重。用氟哌啶醇或赋形剂治疗的未损伤大鼠以及用赋形剂治疗的VMH损伤大鼠的食物摄入量和体重不受这些治疗的影响。
