Shimizu N, Oomura Y, Plata-Salamán C R, Morimoto M
Brain Res. 1987 Jul 21;416(1):153-6. doi: 10.1016/0006-8993(87)91508-3.
Macro-electrophoretic applications of the cellular neurotoxin ibotenic acid into the ventromedial hypothalamic nucleus (VMH) resulted in hyperphagia and obesity in male rats. Histological examination showed a reduction in the number of neuronal VMH cell bodies with glial proliferation without evidence of non-specific damage. This supports the hypothesis that hyperphagia and obesity after VMH lesions are related to destruction of neurons intrinsic to the VMH.
将细胞神经毒素鹅膏蕈氨酸进行宏观电泳注射到雄性大鼠的腹内侧下丘脑核（VMH）中，会导致大鼠出现摄食过量和肥胖。组织学检查显示，VMH神经元细胞体数量减少，伴有胶质细胞增生，且无非特异性损伤迹象。这支持了以下假说：VMH损伤后的摄食过量和肥胖与VMH内在神经元的破坏有关。
