Division of Pediatrics and Neonatal Critical Care, "A. Béclère" Medical Center, South Paris University Hospitals, APHP, Paris, France.
Division of Pediatrics and Neonatal Critical Care, "A. Béclère" Medical Center, South Paris University Hospitals, APHP, Paris, France; Physiopathology and Therapeutic Innovation Unit-INSERM U999, South Paris-Saclay University, Paris - France.
Ultrasound Med Biol. 2020 May;46(5):1258-1262. doi: 10.1016/j.ultrasmedbio.2020.01.018. Epub 2020 Feb 17.
We studied the relationship between ultrasound-assessed lung aeration and inflammation in a particular population of ventilated preterm neonates with mild-to-moderate lung inflammation and no congenital heart defect. Lung aeration estimated by a semiquantitative lung ultrasound score significantly correlated with several inflammatory markers both at cellular (neutrophil count in bronchoalveolar lavage: ρ = 0.400, p = 0.018) and molecular level (total proteins: ρ = 0.524, p = 0.021; interleukine-8: ρ = 0.523, p = 0.021; granulocytes-macrophages colony stimulating factor: ρ = 0.493, p = 0.020; all measured in bronchoalveolar lavage and expressed as epithelial lining fluid concentrations). Lung ultrasound might detect changes in lung aeration attributable to mild-to-moderate local inflammation if cardiogenic lung edema is excluded. Thus, it is possible to describe some levels of lung inflammation with semiquantitative lung ultrasound.
我们研究了通气的早产儿伴有轻度至中度肺炎症且无先天性心脏缺陷的特定人群中，超声评估的肺充气与炎症之间的关系。半定量肺超声评分估计的肺充气与细胞水平（支气管肺泡灌洗液中的中性粒细胞计数：ρ=0.400，p=0.018）和分子水平（总蛋白：ρ=0.524，p=0.021；白细胞介素 8：ρ=0.523，p=0.021；粒细胞巨噬细胞集落刺激因子：ρ=0.493，p=0.020；所有在支气管肺泡灌洗液中测量并表示为上皮衬里液浓度）的几个炎症标志物均显著相关。如果排除心源性肺水肿，肺超声可能可以检测到轻度至中度局部炎症引起的肺充气变化。因此，半定量肺超声可以描述某些程度的肺炎症。
