School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, PR China; School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
State Key Lab. of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, PR China.
Fitoterapia. 2020 Apr;142:104516. doi: 10.1016/j.fitote.2020.104516. Epub 2020 Feb 17.
A new bilobalide isomer (1), together with two flavonol glycosides (2, 3), have been isolated and elucidated from the extract of Ginkgo biloba leaves. Significantly, 1 was a new sesquiterpene lactone with two lactone ring groups, both 2 and 3 were two flavonol glycosides with a same cis-coumaroylated fragment. Their chemical structures were elucidated by NMR and MS spectroscopic date and the absolute configuration of 1 was specific established by Cu-Kα X-ray crystallographic analyses. However, 1-3 showed no obvious anti-platelet aggregation activity.
从银杏叶提取物中分离得到一种新的白果内酯异构体（1），以及两种类黄酮糖苷（2、3）。值得注意的是，1 是一种具有两个内酯环的新的倍半萜内酯，而 2 和 3 则是两个具有相同顺式香豆酰化片段的类黄酮糖苷。它们的化学结构通过 NMR 和 MS 光谱数据得到了阐明，并且通过 Cu-Kα X 射线晶体学分析确定了 1 的绝对构型。然而，1-3 并没有表现出明显的抗血小板聚集活性。
