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来自墨西哥南部热带地区寨卡病毒感染患者的血清细胞因子和趋化因子动态的独特免疫特征。

A unique immune signature of serum cytokine and chemokine dynamics in patients with Zika virus infection from a tropical region in Southern Mexico.

机构信息

Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico.

Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico; Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.

出版信息

Int J Infect Dis. 2020 May;94:4-11. doi: 10.1016/j.ijid.2020.02.014. Epub 2020 Feb 17.

DOI:10.1016/j.ijid.2020.02.014
PMID:
32081772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7362833/
Abstract

OBJECTIVES

To describe the kinetics of circulating cytokines and chemokines in humans with ZIKAV infection.

METHODS

Serum levels of different immune mediators in patients with ZIKAV infection were measured at distinct stages of the disease, as well as in culture supernatants from human monocytes infected with a clinical ZIKAV isolate. We also looked for clinical features associated with specific immune signatures among symptomatic patients.

RESULTS

We evaluated 23 ZIKAV-infected patients. Their mean age was 32 ± 8.3 years and 65% were female. ZIKAV patients showed elevated IL-9, IL-17A, and CXCL10 levels at acute stages of the disease. At day 28, levels of CCL4 and CCL5 were increased, whereas IL-1RA, CXCL8 and CCL2 were decreased. At baseline, IL-7 was increased among patients with headache, whereas CCL2, and CCL3 were decreased in patients with bleeding and rash, respectively. Our clinical ZIKAV isolate induced a broad immune response in monocytes that did not resemble the signature observed in ZIKAV patients.

CONCLUSIONS

We showed a unique immune signature in our cohort of ZIKAV-infected patients. Our study may provide valuable evidence helpful to identify immune correlates of protection against ZIKAV.

摘要

目的

描述 Zika 病毒感染者体内循环细胞因子和趋化因子的动力学变化。

方法

在疾病的不同阶段以及用人单核细胞感染临床 Zika 分离株的培养上清液中，测量 Zika 病毒感染者血清中不同免疫介质的水平。我们还寻找了与症状患者特定免疫特征相关的临床特征。

结果

我们评估了 23 例 Zika 病毒感染者。他们的平均年龄为 32 ± 8.3 岁，65%为女性。Zika 病毒感染者在疾病的急性期表现出升高的 IL-9、IL-17A 和 CXCL10 水平。在第 28 天，CCL4 和 CCL5 水平增加，而 IL-1RA、CXCL8 和 CCL2 减少。在基线时，头痛患者的 IL-7 增加，而出血和皮疹患者的 CCL2 和 CCL3 分别减少。我们的临床 Zika 分离株在单核细胞中诱导了广泛的免疫反应，与 Zika 病毒感染者观察到的特征不同。

结论

我们在 Zika 病毒感染者的队列中显示了一个独特的免疫特征。我们的研究可能为识别针对 Zika 病毒的免疫保护相关因素提供有价值的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe7f/7362833/48b6ef9902c6/nihms-1594355-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe7f/7362833/962095d196ac/nihms-1594355-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe7f/7362833/93f7db5db2c5/nihms-1594355-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe7f/7362833/48b6ef9902c6/nihms-1594355-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe7f/7362833/962095d196ac/nihms-1594355-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe7f/7362833/93f7db5db2c5/nihms-1594355-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe7f/7362833/48b6ef9902c6/nihms-1594355-f0003.jpg

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2
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