Fathi Afshin, Amani Firouz, Mazhari Nahaleh
Department of Pediatric Hematology-Oncology, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran.
Department of Community Medicine, School of medicine, Ardabil University of Medical Science, Ardabil, Iran.
Mater Sociomed. 2019 Dec;31(4):294-297. doi: 10.5455/msm.2019.31.294-297.
The most effective way to prevent thalassemia is to screen for the disease at the population level and then to evaluate the molecularity of individuals. Considering the importance of minor β-thalassemia and its high prevalence in societies.
to investigate the incidence of minor β-thalassemia among Individuals participated in Premarital Screening Program in Ardabil province: North-west of Iran.
This descriptive cross-sectional study was conducted on 39620 individuals participated in the national screening program for Minor β-Thalassemia. Of them 1925 cases had mean corpuscular volume (MCV) < 80 in one person or couple which referred to HbA2 concentration check.
Of all 1925 cases, 95 cases (4.93%) had HbA2>3.5 and defined as Minor β-Thalassemia. The total incidence of minor β-thalassemia among all participated people was 2.4%. Of thalassemia cases 48.4% were women and 51.6% were men. Of all β-thalassemia cases, 49.5% live in Ardabil city and rest of them live in other cities.
Results showed that the prevalence of minor β-thalassemia in Ardabil province was lower than country average rate and a study should be done in future for exact estimation of the disease.
预防地中海贫血最有效的方法是在人群层面进行疾病筛查，然后评估个体的分子情况。考虑到轻度β地中海贫血的重要性及其在社会中的高患病率。
调查参与伊朗西北部阿尔达比勒省婚前筛查项目的个体中轻度β地中海贫血的发病率。
这项描述性横断面研究针对39620名参与全国轻度β地中海贫血筛查项目的个体展开。其中，1925例个体或夫妻的平均红细胞体积（MCV）<80，需进行HbA2浓度检查。
在所有1925例病例中，95例（4.93%）HbA2>3.5，被定义为轻度β地中海贫血。所有参与人群中轻度β地中海贫血的总发病率为2.4%。在地中海贫血病例中，48.4%为女性，51.6%为男性。在所有β地中海贫血病例中，49.5%居住在阿尔达比勒市，其余居住在其他城市。
结果显示，阿尔达比勒省轻度β地中海贫血的患病率低于全国平均水平，未来应开展研究以准确估计该疾病。
