Aldershvile J, Dietrichson O, Hardt F, Nielsen J O
Acta Pathol Microbiol Scand C. 1977 Feb;85(1):26-32. doi: 10.1111/j.1699-0463.1977.tb03607.x.
The number of circulating T and B lymphocytes was estimated in 25 patients with biopsy-verified chronic non alcoholic liver disease. Fifteen of these had circulating HBSAg and/or anti-HBSAg and 10 were without these markers of HB virus infection. In both groups of patients a significant decrease of T cells and a parallel significant increase in null cells was found, but any difference with respect to T and null cells in patients in the two groups was not observed. Liver biopsies from five of the patients with and four without HBSAg and/or anti-HBSAg were studied for the presence of immunoglobulin bearing cells. In three out of five liver biopsies from the HBSAg and/or Ab positive patients and in two out of the four liver biopsies from the HBSAg and anti-HBSAg negative patients, a heavy periportal infiltration with plasma cells was found. However, the number and classes of the immunoglobulin containing cells could not be correlated either to the histological evaluation of the stage of activity of the liver disease or to the markers for HB virus infection. The immunological findings in the two groups of patients with chronic liver disease seem to be of the same nature and are most likely a consequence of the liver disease and not the cause of it.
对25例经活检证实为慢性非酒精性肝病的患者的循环T淋巴细胞和B淋巴细胞数量进行了估计。其中15例患者循环中存在乙肝表面抗原（HBSAg）和/或抗乙肝表面抗原（anti - HBSAg），10例患者没有这些乙肝病毒感染标志物。在两组患者中均发现T细胞显著减少，同时空细胞显著增加，但未观察到两组患者在T细胞和空细胞方面存在任何差异。对5例有HBSAg和/或抗HBSAg的患者及4例无HBSAg和/或抗HBSAg的患者进行肝脏活检，研究含免疫球蛋白细胞的存在情况。在HBSAg和/或抗体阳性患者的5例肝脏活检中有3例，以及HBSAg和抗HBSAg阴性患者的4例肝脏活检中有2例，发现门周有大量浆细胞浸润。然而，含免疫球蛋白细胞的数量和类别与肝病活动期的组织学评估以及乙肝病毒感染标志物均无相关性。两组慢性肝病患者的免疫学发现似乎性质相同，很可能是肝病的结果而非病因。
