Ferraris Fausto Klabund, Garcia Esdras Barbosa, Chaves Amanda da Silva, de Brito Thais Morais, Doro Laís Higino, Félix da Silva Naína Monsores, Alves Amanda Soares, Pádua Tatiana Almeida, Henriques Maria das Graças M O, Cardoso Machado Tiago Savignon, Amendoeira Fabio Coelho
Laboratory of Pharmacology, Department of Pharmacology and Toxicology, National Institute of Health Quality Control (INCQS)-Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Laboratory of Applied Pharmacology, Institute of Drug Technology (Far-Manguinhos)-Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Front Endocrinol (Lausanne). 2020 Jan 31;10:943. doi: 10.3389/fendo.2019.00943. eCollection 2019.
Evidence demonstrates the bidirectional communication and regulation between the neuroendocrine and immune systems. Thyroid hormones play key roles in nervous system development and can exert influence on various immune cells contributing to pathophysiological conditions. Octyl methoxycinnamate (OMC) is one of the most commonly used UV filters, and and studies have found thyroid disrupting effects. The present study assessed whether OMC administration in mice dams during the lactational period can cause thyroid disruption and generate immunologic alterations in the offspring. Indirect exposure to the OMC (1,000 mg/kg) in the lactational period affected neurodevelopment parameters, such as delayed eye-opening and weight gain in mice of both sexes, and these alterations are corroborated by the decrease in the T4 levels present in the pups' blood. No significant changes were observed in the thymus of these pups, but the number of lymphocytes increased in the spleen of the animals exposed to OMC, similar to the animals treated with propyl-thiouracil (PTU), a well-known thyroid disruptor. OMC modulated the percentage of leukocyte populations in peripheral blood, and the number of circulating polymorphonuclear cells increased two-fold. , OMC exhibited an inhibitory effect on splenocyte proliferation and IL-2 production induced by anti-CD3 antibody; however, this effect was reversed with the addition of T4 in the cell culture. In summary, the results of the present study demonstrate the influence of OMC on thyroid dysregulation and its impact on the modulation of the immune system in mice pups.
有证据表明神经内分泌系统和免疫系统之间存在双向通信和调节。甲状腺激素在神经系统发育中起关键作用，并可对导致病理生理状况的各种免疫细胞产生影响。桂皮酸盐（OMC）是最常用的紫外线过滤剂之一，已有研究发现其具有甲状腺干扰作用。本研究评估了哺乳期母鼠给予OMC是否会导致甲状腺功能紊乱并在后代中产生免疫改变。哺乳期间接接触OMC（1000mg/kg）会影响神经发育参数，如两性小鼠的睁眼延迟和体重增加，幼崽血液中T4水平的降低也证实了这些改变。这些幼崽的胸腺未观察到明显变化，但接触OMC的动物脾脏中的淋巴细胞数量增加，类似于用丙硫氧嘧啶（PTU，一种著名的甲状腺干扰物）处理的动物。OMC调节外周血中白细胞群体的百分比，循环多形核细胞数量增加两倍。此外，OMC对抗CD3抗体诱导的脾细胞增殖和IL-2产生具有抑制作用；然而，在细胞培养中加入T4后，这种作用被逆转。总之，本研究结果证明了OMC对甲状腺功能失调的影响及其对幼鼠免疫系统调节的作用。
