Zhang Jingkai, Huang Chao, Meng Zhaowei, Fan Yaguang, Yang Qing, Zhang Wenjuan, Gao Yuxia, Yang Zhenwen, Cai Heng, Bian Bo, Li Yongle, Yu Xuefang, Du Xin, Xu Shaopeng, Nie Jing, Liu Ming, Sun Jinhong, Zhang Qing, Gao Ying, Song Kun, Wang Xing, Zhao Li
Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.
Hull York Medical School, University of Hull, Hull, UK.
Int J Endocrinol. 2019 Dec 30;2019:6053068. doi: 10.1155/2019/6053068. eCollection 2019.
Both hypertension and subclinical thyroid dysfunction (STD) have high prevalence and clinical importance, but their relationship is still a matter of debate. We aimed to explore gender-specific difference on the association between hypertension and STD in Chinese.
We recruited 13,380 ostensible healthy participants (8,237 men and 5,143 women). The associations between hypertension and STD were analyzed on a gender-based setting after dividing STD into subclinical hypothyroidism, subclinical hyperthyroidism and further subgrouped euthyroidism. Crude and adjusted odds ratios of STD for hypertension were analyzed by binary logistic regression.
An increasing trend of hypertension prevalence was found along with aging in both genders. Yet, higher male hypertension prevalence was found until 65 years, and then it intersected with female hypertension prevalence. Women had significantly higher propensity for STD than men. Yet, in elderly participants, this gender-specific difference became less obvious. We displayed detrimental effects for subclinical hypothyroidism in both genders after multiple-covariate adjustments, yet no such effects were shown for subclinical hyperthyroidism. Moreover, females with subclinical hypothyroidism were more likely to be associated with hypertension than males, and the corresponding odds ratios were 1.619 ( < 0.01) and 1.557 ( < 0.01) and 1.557 ( < 0.01) and 1.557 ( < 0.01) and 1.557 ( < 0.01) and 1.557 ( < 0.01) and 1.557 (.
We demonstrate that hypertension is associated with subclinical hypothyroidism, but not with subclinical hyperthyroidism. Moreover, females with subclinical hypothyroidism are more likely to be associated with hypertension than males.
高血压和亚临床甲状腺功能障碍（STD）都具有高患病率和临床重要性，但其关系仍存在争议。我们旨在探讨中国人群中高血压与STD关联的性别差异。
我们招募了13,380名表面健康的参与者（8237名男性和5143名女性）。在将STD分为亚临床甲状腺功能减退、亚临床甲状腺功能亢进以及进一步细分的甲状腺功能正常亚组后，基于性别对高血压与STD之间的关联进行分析。通过二元逻辑回归分析高血压患STD的粗比值比和调整后比值比。
在两性中均发现高血压患病率随年龄增长呈上升趋势。然而，在65岁之前男性高血压患病率较高，之后与女性高血压患病率相交。女性患STD的倾向明显高于男性。然而，在老年参与者中，这种性别差异变得不那么明显。在进行多变量调整后，我们显示亚临床甲状腺功能减退对两性均有不利影响，但亚临床甲状腺功能亢进未显示出此类影响。此外，亚临床甲状腺功能减退的女性比男性更易患高血压，相应的比值比分别为1.619（<0.0１）和1.557（<0.01）以及1.557（<0.01）和1.557（<0.01）和1.557（<0.01）和1.557（<0.01）和1.557（。
我们证明高血压与亚临床甲状腺功能减退有关，但与亚临床甲状腺功能亢进无关。此外，亚临床甲状腺功能减退的女性比男性更易患高血压。
