Alsulami Salhah Saleh, Baig Mukhtiar, Albeladi Atheer Hameed, Alyoubi Shahad Bandar, Alsubaie Shahad Alhumaidi, Albeladi Samah Abdulsalam, Ghamri Kholoud Alawi, Alraiqi Abeer Mohammed Saeed, Alyoubi Safa Mobarak, Almutairi Wesam Aied
Department of Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Internal Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Saudi J Med Med Sci. 2023 Jul-Sep;11(3):250-256. doi: 10.4103/sjmms.sjmms_225_22. Epub 2023 Jul 15.
Several studies worldwide have studied the correlation between subclinical hypothyroidism (SCH), and metabolic syndrome (MetS), but have reported inconsistent findings.
To assess the correlation between SCH and MetS in a population from Saudi Arabia.
This retrospective study was conducted at King Abdulaziz University Hospital and analyzed all thyroid function tests conducted between January 1, 2019, to December 31, 2021. A predesigned checklist was used to collect data about patients' characteristics such as age, gender, nationality, TSH, FT4 level, and MetS components.
A total of 41,519 thyroid function tests were conducted during the study period. From this, 1303 (3.1%) patients were found to have SCH, with the majority being females (74.4%). The prevalence did not differ according to gender but increased to 3.5% among those aged >60 years. MetS components between mildly and markedly elevated TSH were significant for total cholesterol (P < 0.001) and high-density lipoprotein cholesterol (P < 0.05). Male patients with SCH were at a higher risk of developing diabetes (P < 0.001) and hypertension (P < 0.02), than female patients with SCH. After adjusting for age, in the multiple stepwise linear regression analysis, a significant association was found between TSH levels and ALT (odds ratio: 0.77) and SBP (odds ratio: 0.35).
The study demonstrated that the prevalence of SCH is similar between both genders but increases with age. MetS components were abnormal in patients aged >50 years and in males with SCH. SCH and MetS components were found to be correlated, and thus monitoring these variables in patients with SCH is advisable.
全球多项研究探讨了亚临床甲状腺功能减退（SCH）与代谢综合征（MetS）之间的相关性，但结果并不一致。
评估沙特阿拉伯人群中SCH与MetS之间的相关性。
本回顾性研究在阿卜杜勒阿齐兹国王大学医院进行，分析了2019年1月1日至2021年12月31日期间进行的所有甲状腺功能测试。使用预先设计的检查表收集患者的特征数据，如年龄、性别、国籍、促甲状腺激素（TSH）、游离甲状腺素（FT4）水平和代谢综合征的组成成分。
研究期间共进行了41519次甲状腺功能测试。其中，1303例（3.1%）患者被诊断为SCH，大多数为女性（74.4%）。患病率在性别上无差异，但在60岁以上人群中升至3.5%。轻度和显著升高的TSH之间的代谢综合征组成成分在总胆固醇（P < 0.001）和高密度脂蛋白胆固醇（P < 0.05）方面存在显著差异。患有SCH的男性患者患糖尿病（P < 0.001）和高血压（P < 0.02）的风险高于患有SCH的女性患者。在调整年龄后，多步线性回归分析发现TSH水平与丙氨酸转氨酶（ALT）（比值比：0.77）和收缩压（SBP）（比值比：0.35）之间存在显著关联。
该研究表明，SCH的患病率在两性之间相似，但随年龄增长而增加。50岁以上患者和患有SCH的男性患者的代谢综合征组成成分异常。SCH与代谢综合征组成成分之间存在相关性，因此建议对SCH患者监测这些变量。
