非甾体抗炎药会降低自体血胸膜固定术的疗效。
Non-steroid anti-inflammatory drugs reduce the efficacy of autologous blood pleurodesis.
作者信息
Yalçınkaya Serhat, Yalçınkaya Ulviye
机构信息
Department of Thoracic Surgery, Kütahya Health Sciences University, Medical Faculty, Kütahya, Turkey.
Department of Surgical Pathology, Uludağ University, Medical Faculty, Bursa, Turkey.
出版信息
Turk Gogus Kalp Damar Cerrahisi Derg. 2019 Jun 5;27(3):343-349. doi: 10.5606/tgkdc.dergisi.2019.17544. eCollection 2019 Jul.
BACKGROUND
This study aims to perform autologous blood pleurodesis in an animal model and investigate the effects of paracetamol and diclofenac on autologous blood pleurodesis.
METHODS
We divided 42 female Wistar albino rats (aged three months; average weight 275±25 g) into three major groups of 14. Each major group was further divided into two subgroups of seven rats to be sacrificed at seven days for early changes and 21 days for late changes. We performed autologous blood pleurodesis in all rats at a dose of 3 mL/kg. Group C (control group) was administered saline, group P was administered paracetamol, and group D was administered diclofenac for the postoperative five consecutive days as a single dose intraperitoneally. We sacrificed the rats at the designated dates and removed the thoracic cages en bloc.
RESULTS
According to macroscopical and microscopical evaluation of the specimens, paracetamol led to a similar degree of adhesions with saline, whereas diclofenac significantly reduced the intensity of the desired adhesions between the two pleural sheets (p=0.05).
CONCLUSION
Using anti-inflammatory analgesics following autologous blood pleurodesis may lead to unsuccessful outcome of the procedure.
背景
本研究旨在在动物模型中进行自体血胸膜固定术，并研究对乙酰氨基酚和双氯芬酸对自体血胸膜固定术的影响。
方法
我们将42只雌性Wistar白化大鼠（3个月龄；平均体重275±25克）分为三大组，每组14只。每个大组进一步分为两个亚组，每组7只大鼠，分别在7天和21天处死，以观察早期和晚期变化。我们对所有大鼠进行了剂量为3 mL/kg的自体血胸膜固定术。C组（对照组）腹腔注射生理盐水，P组腹腔注射对乙酰氨基酚，D组腹腔注射双氯芬酸，术后连续5天每天单次给药。我们在指定日期处死大鼠，并整块取出胸腔。
结果
根据标本的宏观和微观评估，对乙酰氨基酚导致的粘连程度与生理盐水相似，而双氯芬酸显著降低了两层胸膜之间预期粘连的强度（p=0.05）。
结论
自体血胸膜固定术后使用抗炎镇痛药可能导致手术结果失败。
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