自体血胸腔内注射治疗自发性气胸持续性漏气——其安全性与有效性是否匹配？
Intrapleural instillation of autologous blood for persistent air leak in spontaneous pneumothorax- is it as effective as it is safe?
作者信息
Karangelis Dimos, Tagarakis Georgios I, Daskalopoulos Marios, Skoumis Georgios, Desimonas Nicholaos, Saleptsis Vasileios, Koufakis Theocharis, Drakos Athanasios, Papadopoulos Dimitrios, Tsilimingas Nikolaos B
机构信息
Department of Cardiovascular and Thoracic Surgery, University Hospital of Thessaly, Larissa, Greece.
出版信息
J Cardiothorac Surg. 2010 Aug 17;5:61. doi: 10.1186/1749-8090-5-61.
OBJECTIVE
The aim of the present study was to evaluate the efficacy of autologous blood pleurodesis in the management of persistent air leak in spontaneous pneumothorax.
PATIENTS AND METHODS
A number of 15 patients (10 male and 5 female) were included in this prospective study between March 2005 and December 2009. The duration of the air leak exceeded 7 days in all patients. The application of blood pleurodesis was used as the last preoperative conservative method of treatment in 12 patients. One patient refused surgery and two were ineligible for operation due to their comorbidities. A blood sample of 50 ml was obtained from the patient's femoral vein and immediately introduced into the chest tube.
RESULTS
A success rate of 27% was observed having the air leak sealed in 4 patients in less than 24 hours.
CONCLUSION
Despite our disappointingly poor outcome, the authors believe that the procedure's safety, convenience and low cost establish it as a worth trying method of conservative treatment for patients with the aforementioned pathology for whom no other alternative than surgery would be a choice.
目的
本研究旨在评估自体血胸膜固定术治疗自发性气胸持续性漏气的疗效。
患者与方法
2005年3月至2009年12月期间，15例患者（10例男性，5例女性）纳入本前瞻性研究。所有患者漏气时间均超过7天。12例患者将血胸固定术作为术前最后的保守治疗方法。1例患者拒绝手术，2例因合并症不适合手术。从患者股静脉采集50ml血液样本，立即注入胸管。
结果
4例患者在24小时内漏气停止，成功率为27%。
结论
尽管结果令人失望，但作者认为该手术的安全性、便利性和低成本使其成为上述病理患者保守治疗的一种值得尝试的方法，对于这些患者而言，除手术外别无选择。
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