Şahin Murat, Yenigün Mustafa Bülent, Kocaman Gökhan, Duman Elif, Sakallı Mehmet Ali, Özkan Murat, Yüksel Cabir, Kayı Cangır Ayten, Kutlay Hakan, Akal Murat, Enön Serkan
Department of Thoracic Surgery, Dr. Abdurrahman Yurtarslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.
Department of Thoracic Surgery, Ankara University Faculty of Medicine Ibn-i Sina Hospital, Ankara, Turkey.
Turk Gogus Kalp Damar Cerrahisi Derg. 2019 Jun 25;27(3):367-373. doi: 10.5606/tgkdc.dergisi.2019.17695. eCollection 2019 Jul.
This study aims to evaluate the outcomes of sublobar resections in patients with early-stage non-small cell lung cancer and to investigate the factors affecting survival.
Medical files of a total of 63 patients (52 males, 11 females; mean age 64 years; range, 39 to 81 years) who underwent sublobar resection for suspected or known early-stage non-small cell lung cancer between January 2001 and August 2013 were retrospectively reviewed. Data including demographic characteristics of the patients, comorbid conditions, smoking status, surgical margin, visceral pleura invasion, distance from surgical margin to tumor, tumor size, pathological N status, cell type, tumor localization, and recurrences were recorded.
Survival was significantly longer in the patients with negative surgical margin for tumor (R0) than in those with positive margin (R1) (94.1 months vs. 32.2 months, p<0.01). Survival was also significantly longer in the patients without lymphatic invasion (p<0.01).
In early-stage lung tumors, sublobar resection can be performed, if complete resection is performed. Lymphatic invasion is a negative prognostic factor for survival following sublobar resection.
本研究旨在评估早期非小细胞肺癌患者亚肺叶切除的疗效，并探讨影响生存的因素。
回顾性分析2001年1月至2013年8月期间因疑似或已知早期非小细胞肺癌接受亚肺叶切除的63例患者（男性52例，女性11例；平均年龄64岁；范围39至81岁）的病历。记录患者的人口统计学特征、合并症、吸烟状况、手术切缘、脏层胸膜侵犯、手术切缘至肿瘤的距离、肿瘤大小、病理N分期、细胞类型、肿瘤定位和复发情况等数据。
肿瘤手术切缘阴性（R0）的患者生存期明显长于切缘阳性（R1）的患者（94.1个月对32.2个月，p<0.01）。无淋巴侵犯的患者生存期也明显更长（p<0.01）。
在早期肺肿瘤中，若能完整切除，可进行亚肺叶切除。淋巴侵犯是亚肺叶切除术后生存的不良预后因素。
