International Genomics Research Center (IGRC), Jiangsu University, Zhenjiang 212013, China.
Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang 212013, China.
J Immunol Res. 2019 Dec 30;2019:2835256. doi: 10.1155/2019/2835256. eCollection 2019.
, as a nonfermentation Gram-negative bacterium, mainly cause nosocomial infections in critically ill patients. With the widespread of multidrug-resistant , the urgency of developing effective therapy options has been emphasized nowadays. Outer membrane vesicles derived from bacteria show potential vaccine effects against bacterial infection in recent study. Our present research is aimed at investigating the mechanisms involved in immune protection of mice after outer membrane vesicle immunization. As our data showed, the outer membrane vesicle from an clinical strain could activate bone marrow-derived dendritic cells (BMDCs) to promote Th2 activity together with humoral immune responses to -induced sepsis, which might enlighten people to have a better understanding of OMVs' role as a vaccine to prevent bacterial infections.
铜绿假单胞菌作为一种非发酵革兰氏阴性菌，主要在重症患者中引起医院获得性感染。随着多药耐药铜绿假单胞菌的广泛传播，开发有效治疗方法的紧迫性日益凸显。最近的研究表明，源自细菌的外膜囊泡具有针对细菌感染的潜在疫苗效果。我们目前的研究旨在探讨外膜囊泡免疫后小鼠免疫保护的机制。正如我们的数据所示，来自临床分离株的外膜囊泡可以激活骨髓来源的树突状细胞（BMDCs），促进 Th2 活性和针对 - 诱导性败血症的体液免疫反应，这可能使人们更好地理解 OMVs 作为预防细菌感染的疫苗的作用。
