Anaesthesiology Department, Beijing Hospital, National Centre of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Neurology Department, Beijing Hospital, National Centre of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Clin Exp Rheumatol. 2021 Jan-Feb;39(1):21-31. doi: 10.55563/clinexprheumatol/iitbcp. Epub 2020 Feb 14.
Fibromyalgia (FM) is the most common chronic pain disease in middle-aged women. Patients may also complain of migraine, irritable bowel syndrome and depression, which seriously affect their work and life, causing huge economic losses to society. However, the pathogenesis of FM is still controversial and the effect of the current treatment is far from satisfactory.
Differentially expressed genes (DEGs) and miRNAs (DEMs) were found between FM and normal blood samples. The pathway and process enrichment analysis of the genes were performed. Protein-protein interaction network were constructed. Hub genes were found and analysed in The Comparative Toxicogenomics Database.
A total of 102 genes were up-regulated and 46 down-regulated, 206 miRNAs down-regulated, and 15 up-regulated in FM. CD38, GATM, HDC, FOS were found as canditate genes. These genes were significantly associated with musculoskeletal disease, mental disorder, immune system disease. There was partial overlap between metformin therapy-related genes and FM-related genes.
We found DEGs and DEMs in FM patients through bioinformatics analysis, which may be involved in the occurrence and development of FM and serve as potential targets for diagnosis and treatment.
纤维肌痛（FM）是中年女性最常见的慢性疼痛疾病。患者还可能会抱怨偏头痛、肠易激综合征和抑郁症，这严重影响了他们的工作和生活，给社会造成了巨大的经济损失。然而，FM 的发病机制仍存在争议，目前的治疗效果远不理想。
在 FM 和正常血液样本之间发现差异表达基因（DEGs）和微小 RNA（DEMs）。对基因进行通路和过程富集分析。构建蛋白质-蛋白质相互作用网络。在比较毒理学基因组数据库中发现和分析关键基因。
FM 中共有 102 个基因上调和 46 个下调，206 个 miRNA 下调，15 个上调。发现 CD38、GATM、HDC、FOS 为候选基因。这些基因与肌肉骨骼疾病、精神障碍、免疫系统疾病显著相关。二甲双胍治疗相关基因与 FM 相关基因之间存在部分重叠。
通过生物信息学分析，我们在 FM 患者中发现了差异表达基因和微小 RNA，它们可能参与了 FM 的发生和发展，可作为诊断和治疗的潜在靶点。
