OCEL1 低表达与人类非小细胞肺癌的不良预后相关。
Low OCEL1 expression is associated with poor prognosis in human non-small cell lung cancer.
机构信息
Department of Respiratory and Infectious Disease of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China.
出版信息
Cancer Biomark. 2020;27(4):519-524. doi: 10.3233/CBM-191268.
BACKGROUND
Occludin/ELL domain containing 1 (OCEL1) is a novel discovered protein with its molecular functions remaining unknown and its role in lung cancer has not been directly explored.
OBJECTIVES
This study focused on the role of OCEL1 in the progression and prognosis of non-small cell lung cancer (NSCLC).
METHODS
A public database and tissue samples (80 NSCLC tissue samples and paired normal lung samples) were used to compare differences in OCEL1 expression and investigate its relationship with clinical characteristics and prognosis.
RESULTS
Compared to adjacent normal lung tissue samples, OCEL1 expression was significantly down-regulated in tumor tissues. In addition, there was a negative correlation between OCEL1 and Ki67 expression levels. Low OCEL1 expression was significantly associated with lymph node metastasis, higher TNM stage, and poor prognosis. Importantly, multivariate analysis identified OCEL1 expression as an independent predictor for unfavorable NSCLC prognosis.
CONCLUSIONS
These results indicated that OCEL1 protein may serve as a novel prognostic biomarker in NSCLC.
背景
Occludin/ELL 结构域包含蛋白 1（OCEL1）是一种新发现的蛋白，其分子功能尚不清楚，其在肺癌中的作用尚未被直接探索。
目的
本研究旨在探讨 OCEL1 在非小细胞肺癌（NSCLC）进展和预后中的作用。
方法
利用公共数据库和组织样本（80 例 NSCLC 组织样本和配对的正常肺组织样本）比较 OCEL1 表达的差异，并探讨其与临床特征和预后的关系。
结果
与相邻的正常肺组织样本相比，OCEL1 在肿瘤组织中的表达明显下调。此外，OCEL1 与 Ki67 表达水平呈负相关。低 OCEL1 表达与淋巴结转移、较高的 TNM 分期和不良预后显著相关。重要的是，多因素分析确定 OCEL1 表达是 NSCLC 预后不良的独立预测因子。
结论
这些结果表明，OCEL1 蛋白可能是 NSCLC 的一种新的预后生物标志物。
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