晚期糖基化终产物蓄积与老年人群认知功能下降相关：长滨研究。
Advanced Glycation End Product Accumulation is Associated with Lower Cognitive Performance in an Older General Population: The Nagahama Study.
机构信息
Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Sakyo-ku Kyoto, Japan.
Air Water Biodesign Inc., Kobe, Hyogo, Japan.
出版信息
J Alzheimers Dis. 2020;74(3):741-746. doi: 10.3233/JAD-190878.
Accumulation of advanced glycation end products (AGEs) has been linked with cognitive decline as a risk factor based on the analysis in small populations. We investigated the association between skin autofluorescence of AGEs and global cognitive function in a Japanese older (≥60 years) population (n = 4,041). The AGEs quartiles were inversely associated with the Revised Hasegawa's Dementia Scale score (Q1: reference, Q2: β= -0.011, p = 0.537, Q3: β= -0.043, p = 0.016, Q4: β= -0.064, p < 0.001) independent of major risk factors. Accumulation of AGEs was associated with lower cognitive performance in older adults.
已有分析表明，晚期糖基化终产物（AGEs）的积累与认知能力下降有关，这是一个风险因素。我们在一个日本老年（≥60 岁）人群（n=4041）中调查了 AGEs 皮肤自发荧光与整体认知功能之间的关系。AGEs 四分位与修订后的长谷川痴呆量表评分呈负相关（Q1：参考，β=−0.011，p=0.537，Q3：β=−0.043，p=0.016，Q4：β=−0.064，p<0.001），独立于主要危险因素。AGEs 的积累与老年人较低的认知表现有关。
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