晚期糖基化终产物与老年人跌倒风险的关系：Yakumo 研究。

Association between advanced glycation end-products and fall risk in older adults: The Yakumo Study.

机构信息

Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Department of Orthopedic Surgery, Aichi Medical University Medical Center, Okazaki, Japan.

出版信息

Geriatr Gerontol Int. 2024 Jun;24(6):517-522. doi: 10.1111/ggi.14871. Epub 2024 Apr 21.

DOI:10.1111/ggi.14871

PMID:38644665

Abstract

AIM

Advanced glycation end-products (AGEs) are irreversibly and heterogeneously formed compounds during the non-enzymatic modification of macromolecules, such as proteins. Aging and lifestyle habits, such as high-fat and high-protein diets, and smoking, promote AGEs accumulation. This study aimed to investigate the relationship between fall risk and AGEs in community-dwelling older adults.

METHODS

This cross-sectional study included patients from the 2022 Yakumo Study who were evaluated for fall risk index 5-items version, locomotive syndrome stage and AGEs. AGEs were evaluated using Skin autofluorescence (SAF) measured by the AGE reader (DiagnOptics Technologies BV, Groningen, the Netherlands). We divided the participants into two groups according to the presence or absence of fall risk (fall risk index 5-items version ≥6 or not), and investigated the factors associated with fall risk.

RESULTS

The fall risk group had a higher age and SAF, and a higher proportion of locomotive syndrome stage >2 than the without fall risk group in patients aged ≥65 years (P < 0.01). The multivariate logistic regression analysis after adjustment of age, sex and body mass index showed that locomotive syndrome stage ≥2 and SAF were independent associators of fall risk in older adults (odds ratio 3.26, P < 0.01, odds ratio 2.96, P < 0.05, respectively). The optimal cutoff value of the SAF for fall risk was 2.4 (area under the curve 0.631; 95% CI 0.53-0.733; sensitivity 0.415; specificity 0.814; P < 0.05).

CONCLUSION

The accumulation of AGEs in skin tissues can be used to screen for fall risk comprehensively. Geriatr Gerontol Int 2024; 24: 517-522.

摘要

目的

晚期糖基化终产物（AGEs）是大分子（如蛋白质）非酶促修饰过程中不可逆和不均匀形成的化合物。衰老和生活方式习惯，如高脂肪和高蛋白饮食以及吸烟，会促进 AGEs 的积累。本研究旨在探讨社区老年人跌倒风险与 AGEs 之间的关系。

方法

本横断面研究纳入了 2022 年药师野研究中接受跌倒风险指数 5 项版本、运动综合征阶段和 AGEs 评估的患者。AGEs 通过 AGE 阅读器（荷兰格罗宁根诊断光学技术公司）测量的皮肤自发荧光（SAF）进行评估。我们根据是否存在跌倒风险（跌倒风险指数 5 项版本≥6 或<6）将参与者分为两组，并调查了与跌倒风险相关的因素。

结果

在≥65 岁的患者中，跌倒风险组的年龄和 SAF 较高，运动综合征阶段>2 的比例也高于无跌倒风险组（P<0.01）。在调整年龄、性别和体重指数后进行多变量逻辑回归分析，结果显示，运动综合征阶段≥2 和 SAF 是老年人跌倒风险的独立相关因素（优势比 3.26，P<0.01，优势比 2.96，P<0.05）。SAF 预测跌倒风险的最佳截断值为 2.4（曲线下面积 0.631；95%置信区间 0.53-0.733；敏感性 0.415；特异性 0.814；P<0.05）。