固定导致大鼠肌肉疼痛的机制。
Mechanisms underlying immobilization-induced muscle pain in rats.
机构信息
Department of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Department of Rehabilitation, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan.
出版信息
Muscle Nerve. 2020 May;61(5):662-670. doi: 10.1002/mus.26840. Epub 2020 Mar 8.
INTRODUCTION
We investigated the mechanisms underlying immobilization-induced muscle pain in rats.
METHODS
In rat skeletal muscle, pressure pain threshold (PPT) of the gastrocnemius muscle was measured, and nerve growth factor (NGF) level, peripheral nerve fiber density, macrophage number, and interleukin-1β (IL-1β) mRNA expression were examined. An NGF receptor inhibitor was injected intramuscularly to assess the relationship between PPT and NGF levels.
RESULTS
Immobilization resulted in a decrease in PPT and increases in NGF level, C-fiber density, M1 macrophage number, and IL-1β mRNA expression. Injection of NGF receptor inhibitor reversed the decrease in PPT.
DISCUSSION
NGF upregulation may be a major contributor to immobilization-induced muscle pain. The increases in C-fiber density, M1 macrophage number, and IL-1β mRNA expression may be related to immobilization-induced muscle pain.
引言
我们研究了固定引起的大鼠肌肉疼痛的机制。
方法
在大鼠骨骼肌中，测量了腓肠肌的压痛阈值（PPT），并检测了神经生长因子（NGF）水平、周围神经纤维密度、巨噬细胞数量和白细胞介素-1β（IL-1β）mRNA 表达。肌肉内注射 NGF 受体抑制剂，以评估 PPT 和 NGF 水平之间的关系。
结果
固定导致 PPT 降低，NGF 水平、C 纤维密度、M1 巨噬细胞数量和 IL-1βmRNA 表达增加。注射 NGF 受体抑制剂可逆转 PPT 的降低。
讨论
NGF 的上调可能是固定引起肌肉疼痛的主要原因。C 纤维密度、M1 巨噬细胞数量和 IL-1βmRNA 表达的增加可能与固定引起的肌肉疼痛有关。
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