ICEERS-International Center for Ethnobotanical Education, Research and Service, Barcelona, Spain.
Department of Anthropology, Philosophy and Social Work, Universitat Rovira i Virgili, Medical Anthropology Research Center, Tarragona, Spain.
Phytother Res. 2020 Jul;34(7):1670-1677. doi: 10.1002/ptr.6639. Epub 2020 Feb 21.
The number of patients using cannabis for therapeutic purposes is growing worldwide. While research regarding the treatment of certain diseases/disorders with cannabis and cannabinoids is also expanding, only a few longitudinal studies have assessed the mid-term impacts of medical cannabis use on psychological variables and quality of life (QoL). The aim of the study was to assess the psychological safety and QoL of patients with chronic diseases who self-medicate with cannabis over time. We recruited patients with various chronic diseases who use cannabis and collected data regarding patterns of cannabis use as well as mental health, personality and QoL. Participants were followed-up at baseline, 4, 8 and 12 months. Hair analysis was conducted to confirm the presence of cannabinoids. Personality assessment showed a consistent decrease in self-transcendence and self-directedness scores. Neither cognitive nor psychopathological deterioration was found. There were also no variations in QoL. Mid-term use of medical cannabis seems to show adequate tolerability regarding cognitive and psychopathological abilities, and it may help patients with chronic diseases to maintain an acceptable QoL.
全球范围内，因治疗目的而使用大麻的患者数量正在增长。虽然关于大麻和大麻素治疗某些疾病/障碍的研究也在不断扩展，但只有少数纵向研究评估了医用大麻使用对心理变量和生活质量（QoL）的中期影响。本研究旨在评估长期自我使用大麻的慢性病患者的心理安全性和 QoL。我们招募了使用大麻的各种慢性病患者，并收集了有关大麻使用模式以及心理健康、个性和 QoL 的数据。参与者在基线、4、8 和 12 个月时进行了随访。进行毛发分析以确认是否存在大麻素。个性评估显示自我超越和自我导向得分持续下降。未发现认知或精神病理学恶化。生活质量也没有变化。医用大麻的中期使用在认知和精神病理学能力方面似乎具有足够的耐受性，它可能有助于慢性病患者维持可接受的生活质量。
