Li Jimmy, Areal Cassandra C, Toffa Dènahin Hinnoutondji, Citherlet Daphné, Deacon Charles, Jutras-Aswad Didier, Keezer Mark Robert, Nguyen Dang Khoa
Neurology Division, Centre Hospitalier de l'Université de Sherbrooke (CHUS), Sherbrooke, QC, Canada.
Neurosciences Axis, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Front Neurol. 2023 Mar 6;14:1132106. doi: 10.3389/fneur.2023.1132106. eCollection 2023.
The use of medical cannabis among people with epilepsy (PWE) has been garnering increasing interest. In this scoping review, we aimed to summarize the literature on recreational/non-medical cannabis (NMC) use in PWE, focusing on the experience, habits, and beliefs of PWE regarding NMC.
Four databases (OVID Medline, OVID Embase, Ovid APA PsycInfo, and Web of Science) were searched for studies describing NMC use in PWE. NMC was defined as cannabis products procured from sources other than by prescription. Studies that consisted in original research and that detailed the experience, habits, and/or beliefs of PWE regarding NMC use were included in the analysis. Data pertaining to study identification, demographics, NMC use, and epilepsy characteristics were extracted. Descriptive statistical analyses and reflexive thematic analyses were performed to map these data.
In total, 3,228 records were screened, and 66 were included for analysis: 45 had mainly adult samples, whereas 21 had mainly pediatric samples. Most studies were published after 2010, originated from the USA, and were cross-sectional. The median number of PWE using cannabis in these studies was 24.5 (1-37,945). No studies showcased elderly PWE, and most had predominantly Caucasian samples. The lifetime prevalence of NMC use in PWE was variable, ranging between 0.69 and 76.8%. Factors frequently associated with NMC use in PWE were male sex, younger adult age, and lower education status. Children with epilepsy took NMC primarily for seizure control, using high CBD/THC ratios, and only orally. Adults with epilepsy took NMC for various reasons including recreationally, using variable CBD/THC ratios, and predominantly through smoking. The majority of PWE across all studies perceived that NMC aided in seizure control. Other aspects pertaining to NMC use in PWE were rarely reported and often conflicting.
The literature on NMC use in PWE is sparse and heterogeneous, with many salient knowledge gaps. Further research is necessary to better understanding the experience, habits, and beliefs of PWE pertaining to NMC.
癫痫患者（PWE）使用医用大麻越来越受到关注。在本范围综述中，我们旨在总结关于癫痫患者使用娱乐性/非医用大麻（NMC）的文献，重点关注癫痫患者使用NMC的经历、习惯和信念。
检索了四个数据库（OVID Medline、OVID Embase、Ovid APA PsycInfo和Web of Science），以查找描述癫痫患者使用NMC的研究。NMC被定义为从非处方渠道获得的大麻产品。纳入分析的研究包括原创性研究，且详细描述了癫痫患者使用NMC的经历、习惯和/或信念。提取了与研究识别、人口统计学、NMC使用情况和癫痫特征相关的数据。进行了描述性统计分析和反思性主题分析来梳理这些数据。
共筛选了3228条记录，其中66条纳入分析：45项主要为成人样本，21项主要为儿童样本。大多数研究于2010年后发表，来自美国，且为横断面研究。这些研究中使用大麻的癫痫患者中位数为24.5（1 - 37945）。没有研究展示老年癫痫患者，且大多数样本主要为白种人。癫痫患者使用NMC的终生患病率各不相同，在0.69%至76.8%之间。与癫痫患者使用NMC频繁相关的因素为男性、年轻成年人以及较低的教育水平。癫痫儿童使用NMC主要是为了控制癫痫发作，使用高CBD/THC比例，且仅通过口服。癫痫成人使用NMC的原因多种多样，包括娱乐用途，使用的CBD/THC比例各不相同，且主要通过吸烟。所有研究中的大多数癫痫患者认为NMC有助于控制癫痫发作。关于癫痫患者使用NMC的其他方面报道很少，且常常相互矛盾。
关于癫痫患者使用NMC的文献稀少且异质性大，存在许多显著的知识空白。有必要进行进一步研究以更好地了解癫痫患者使用NMC的经历、习惯和信念。
