División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, México.
División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, México.
Int J Neurosci. 2021 Jan;131(1):49-55. doi: 10.1080/00207454.2020.1733558. Epub 2020 Feb 28.
We conducted a meta-analysis of case-control studies to determine whether leptin levels in serum contribute to the pathogenesis of suicide behavior. PubMed, EBSCO and Science Direct databases were used to search for relevant articles published before January 2020. The systematic review included nine case-control studies that measured leptin levels. The standardized mean difference () and 95% confidence intervals were calculated in a fixed-effects model and a random-effects model when appropriate. The results of our meta-analysis indicated that individuals with suicide behavior presented reduced levels of leptin (: -1.80, 95% CI: -2.21 to -01.38 g/ml, = 0, p(Q) = 0.59). Sensitivity and publication bias analyses confirmed these results. The current meta-analysis suggests that leptin levels might be associated with an increased risk of suicide behavior. However, more studies including larger sample sizes are needed to reach conclusive result.
我们进行了一项病例对照研究的荟萃分析，以确定血清中的瘦素水平是否有助于自杀行为的发病机制。使用 PubMed、EBSCO 和 Science Direct 数据库检索了 2020 年 1 月之前发表的相关文章。系统评价包括了九项测量瘦素水平的病例对照研究。当适当的时候，使用固定效应模型和随机效应模型计算标准化均数差（）和 95%置信区间。我们的荟萃分析结果表明，有自杀行为的个体瘦素水平降低（：-1.80，95%CI：-2.21 至-01.38 g/ml，=0，p(Q)=0.59）。敏感性和发表偏倚分析证实了这些结果。目前的荟萃分析表明，瘦素水平可能与自杀行为的风险增加有关。然而，需要更多包括更大样本量的研究来得出结论性的结果。
