早产儿毛霉感染：泊沙康唑的新用途。
Rhizopus Infection in a Preterm Infant: A Novel Use of Posaconazole.
机构信息
From the Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Department of Pharmacy, Texas Children's Hospital, Houston, Texas.
出版信息
Pediatr Infect Dis J. 2020 Apr;39(4):310-312. doi: 10.1097/INF.0000000000002554.
Posaconazole is a triazole antifungal with activity against Rhizopus, but data on its use and pharmacokinetics in preterm infants are scarce. In this case, a 24 4/7-week neonate's Rhizopus infection is successfully treated with debridement and combination antifungal therapy with amphotericin B, micafungin and enteral posaconazole. This is the first reported posaconazole use in a preterm neonate with Rhizopus.
泊沙康唑是一种三唑类抗真菌药，对根霉属有活性，但早产儿中使用泊沙康唑的相关数据和药代动力学数据有限。本病例中，1 名 24 4/7 周的早产儿通过清创术联合两性霉素 B、米卡芬净和肠内泊沙康唑治疗，成功治愈了根霉属感染。这是首例报道的早产儿使用泊沙康唑治疗根霉属感染的病例。
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